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자연과학대학
화학·나노과학전공
Journal papers
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Cross metathesis assisted solid-phase synthesis of glycopeptoids
Title
Cross metathesis assisted solid-phase synthesis of glycopeptoids
Authors
Khan S.N.
;
Kim A.
;
Grubbs R.H.
;
Kwon Y.-U.
Ewha Authors
권용억
;
Robert H. Grubbs
SCOPUS Author ID
권용억
; Robert H. Grubbs
Issue Date
2012
Journal Title
Organic Letters
ISSN
1523-7060
Citation
Organic Letters vol. 14, no. 12, pp. 2952 - 2955
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
A solid-phase synthesis of glycopeptoids was explored through olefin cross metathesis (CM). Peptoids and sugar derivatives with appropriate olefin moieties were coupled in the presence of an olefin metathesis catalyst to afford glycopeptoids in good yields. This systematic solid-phase CM study can provide facile access to the molecular sources of glycopeptidomimetics and postchemical modifications on various molecular scaffolds. © 2012 American Chemical Society.
DOI
10.1021/ol300808c
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