View : 262 Download: 0

Full metadata record

DC Field Value Language
dc.contributor.author신윤용-
dc.date.accessioned2016-08-28T12:08:13Z-
dc.date.available2016-08-28T12:08:13Z-
dc.date.issued2012-
dc.identifier.issn1016-8478-
dc.identifier.otherOAK-8675-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222554-
dc.description.abstractTo identify specific biomarkers generated upon exposure of L5178Y mouse lymphoma cells to carcinogens, 2-DE and MALDI-TOF MS analysis were conducted using the cellular proteome of L5178Y cells that had been treated with the known carcinogens, 1,2-dibromoethane and O-nitrotoluene and the noncarcinogens, emodin and D-mannitol. Eight protein spots that showed a greater than 1.5-fold increase or decrease in intensity following carcinogen treatment compared with treatment with noncarcinogens were selected. Of the identified proteins, we focused on the candidate biomarker ERM-binding phosphoprotein 50(EBP50), the expression of which was specifically increased in response to treatment with the carcinogens. The expression level of EBP50 was determined by western analysis using polyclonal rabbit anti-EBP50 antibody. Further, the expression level of EBP50 was increased in cells treated with seven additional carcinogens, verifying that EBP50 could serve as a specific biomarker for carcinogens. © 2012 KSMCB.-
dc.languageEnglish-
dc.titleIdentification of EBP50 as a specific biomarker for carcinogens via the analysis of mouse lymphoma cellular proteome-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume33-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage309-
dc.relation.lastpage316-
dc.relation.journaltitleMolecules and Cells-
dc.identifier.doi10.1007/s10059-012-2280-7-
dc.identifier.wosidWOS:000302818700013-
dc.identifier.scopusid2-s2.0-84863449883-
dc.author.googleLee Y.J.-
dc.author.googleChoi I.-K.-
dc.author.googleSheen Y.Y.-
dc.author.googlePark S.N.-
dc.author.googleKwon H.J.-
dc.contributor.scopusid신윤용(6603872711)-
dc.date.modifydate20210301081004-
Appears in Collections:
약학대학 > 약학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE