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dc.contributor.author이화정-
dc.contributor.author윤여준-
dc.contributor.author최진호-
dc.date.accessioned2016-08-28T12:08:12Z-
dc.date.available2016-08-28T12:08:12Z-
dc.date.issued2012-
dc.identifier.issn1176-9114-
dc.identifier.otherOAK-8663-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/222543-
dc.description.abstractA nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT), for taste masking of sildenafil (SDN). To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN-MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA). Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was successfully intercalated into the interlayer space of MMT. The AEA-coated SDN-MMT nanohybrid showed drug release was much suppressed at neutral pH (release rate, 4.70 ± 0.53%), suggesting a potential for drug taste masking at the buccal cavity. We also performed in vitro drug release experiments in a simulated gastric fluid (pH = 1.2) and compared the drug-release profiles of AEA-coated SDN-MMT and Viagra®, an approved dosage form of SDN. As a result, about 90% of SDN was released from the AEAcoated SDN-MMT during the first 2 hours while almost 100% of drug was released from Viagra®. However, an in vivo experiment showed that the AEA-coated SDN-MMT exhibited higher drug exposure than Viagra®. For the AEA-coated SDN-MMT, the area under the plasma concentration- time curve from 0 hours to infinity (AUC0-∞) and maximum concentration (Cmax) were 78.8 ± 2.32 μg · hour/mL and 12.4 ± 0.673 μg/mL, respectively, both of which were larger than those obtained with Viagra® (AUC0-∞ = 69.2 ± 3.19 μg · hour/mL; Cmax = 10.5 ± 0.641 μg/mL). Therefore, we concluded that the MMT-based nanohybrid is a promising delivery system for taste masking of SDN with possibly improved drug exposure. © 2012 Lee et al, publisher and licensee Dove Medical Press Ltd.-
dc.languageEnglish-
dc.titleA nanohybrid system for taste masking of sildenafil-
dc.typeArticle-
dc.relation.volume7-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1635-
dc.relation.lastpage1649-
dc.relation.journaltitleInternational Journal of Nanomedicine-
dc.identifier.doi10.2147/IJN.S28264-
dc.identifier.wosidWOS:000302731300001-
dc.identifier.scopusid2-s2.0-84866745265-
dc.author.googleLee J.-H.-
dc.author.googleChoi G.-
dc.author.googleOh Y.-J.-
dc.author.googlePark J.W.-
dc.author.googleChoy Y.B.-
dc.author.googlePark M.C.-
dc.author.googleYoon Y.J.-
dc.author.googleLee H.J.-
dc.author.googleChang H.C.-
dc.author.googleChoy J.-H.-
dc.contributor.scopusid이화정(57102029300;35069834100)-
dc.contributor.scopusid윤여준(7402126465)-
dc.contributor.scopusid최진호(8044393000)-
dc.date.modifydate20210915113404-
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