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일반대학원
생명·약학부
Journal papers
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Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
Title
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
Authors
Rhee S.G.
;
Woo H.A.
;
Kil I.S.
;
Bae S.H.
Ewha Authors
이서구
;
배수한
;
길인섭
;
우현애
SCOPUS Author ID
이서구
; 길인섭
; 우현애
Issue Date
2012
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258
Citation
Journal of Biological Chemistry vol. 287, no. 7, pp. 4403 - 4410
Indexed
SCI; SCIE; SCOPUS
Document Type
Short Survey
Abstract
Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2O 2. Mammalian cells express six Prx isoforms that are localized to various cellular compartments. The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase. Regulation of Prx via phosphorylation in response to extracellular signals allows the local accumulation of H 2O 2 and thereby enables its messenger function. The fact that the oxidation state of the active site cysteine of Prx can be transferred to other proteins that are less intrinsically susceptible to H 2O 2 also allows Prx to function as an H 2O 2 sensor. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.R111.283432
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