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Extremely low frequency magnetic fields do not elicit oxidativestress in MCF10A cells
- Title
- Extremely low frequency magnetic fields do not elicit oxidativestress in MCF10A cells
- Authors
- Hong M-N.; Han N.-K.; Lee H.-C.; Ko Y.-K.; Chi S.-G.; Lee Y.-S.; Gimm Y.-M.; Myung S.-H.; Lee J.-S.
- Ewha Authors
- 이윤실
- SCOPUS Author ID
- 이윤실
- Issue Date
- 2012
- Journal Title
- Journal of Radiation Research
- ISSN
- 0449-3060
- Citation
- Journal of Radiation Research vol. 53, no. 1, pp. 79 - 86
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The aim of this study was to determine whether extremely low frequency magnetic fields (ELF-MF) could affect intracellular reactive oxygen species (ROS) levels and antioxidant enzyme activity. After MCF10A human breast epithelial cells were exposed to 1 mT of 60 Hz ELF-MF for 4 hours, intracellular ROS level, superoxide dismutase (SOD) activity, and reduced to oxidized glutathione (GSH/GSSG) ratio were measured. The cells exposed to ELF-MF did not evidence statistically significant changes in the above-mentioned biological parameters as compared to either the incubator controls or sham-exposed cells. By way of contrast, the IR-exposed cells exhibited marked changes in ROS level, SOD activity, and GSH/GSSG ratio. When we assessed morphological changes and senescence-associated beta-galactosidase (SA-β-Gal) activity, only the IR-exposed cells were positive. According to our results, it could be concluded that ELF-MF has no effect on intracellular ROS level, SOD activity, and GSH/GSSG ratio under our exposure condition.
- DOI
- 10.1269/jrr.11049
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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