Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 허정원 | * |
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2016-08-28T12:08:39Z | - |
dc.date.available | 2016-08-28T12:08:39Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0732-183X | * |
dc.identifier.other | OAK-8261 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/222186 | - |
dc.description.abstract | Purpose: This study attempted to analyze the prognostic role of single nucleotide polymorphism array (SNP-A) -based karyotying in 133 patients with acute myeloid leukemia with normal karyotype (AML-NK), which presents with diverse clinical outcomes, thus requiring further stratification of patient subgroups according to their prognoses. Patients and Methods: A total of 133 patients with AML-NK confirmed by metaphase cytogenetics (MC) and fluorescent in situ hybridization analysis were included in this study. Analysis by Genome-Wide Human SNP 6.0 Array was performed by using DNAs derived from marrow samples at diagnosis. Results: Forty-three patients (32.3%) had at least one abnormal SNP lesion that was not detected by MC. One hundred thirteen abnormal SNP lesions included 55 losses, 23 gains, and 35 copy-neutral losses of heterozygosity. Multivariate analyses showed that detection of abnormal SNP lesions by SNP-A karyotyping results in an unfavorable prognostic value for overall survival (hazard ratio [HR], 2.69; 95% CI, 1.50 to 4.82; P = .001); other significant prognostic factors included secondary AML (HR, 5.55; 95% CI, 1.80 to 17.14; P = .003), presence of the FLT3 mutation (HR, 3.17; 95% CI, 1.71 to 5.87; P < .001), and age (HR, 1.03; 95% CI, 1.01 to 1.05; P = .020). Conclusion: Our data demonstrated that abnormal SNP lesions detected by SNP-A karyotyping might indicate an adverse prognosis in patients with AML-NK, thus requiring a more sophisticated treatment strategy for improvement of treatment outcomes. © 2011 by American Society of Clinical Oncology. | * |
dc.language | English | * |
dc.title | Adverse prognostic impact of abnormal lesions detected by genome-wide single nucleotide polymorphism array-based karyotyping analysis in acute myeloid leukemia with normal karyotype | * |
dc.type | Article | * |
dc.relation.issue | 35 | * |
dc.relation.volume | 29 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4702 | * |
dc.relation.lastpage | 4708 | * |
dc.relation.journaltitle | Journal of Clinical Oncology | * |
dc.identifier.doi | 10.1200/JCO.2011.35.5719 | * |
dc.identifier.wosid | WOS:000298141700025 | * |
dc.identifier.scopusid | 2-s2.0-83255164849 | * |
dc.author.google | Yi J.H. | * |
dc.author.google | Huh J. | * |
dc.author.google | Kim H.-J. | * |
dc.author.google | Kim S.-H. | * |
dc.author.google | Kim Y.-K. | * |
dc.author.google | Sohn S.K. | * |
dc.author.google | Moon J.H. | * |
dc.author.google | Kim S.H. | * |
dc.author.google | Kim K.H. | * |
dc.author.google | Won J.H. | * |
dc.author.google | Mun Y.C. | * |
dc.author.google | Kim H. | * |
dc.author.google | Park J. | * |
dc.author.google | Jung C.W. | * |
dc.author.google | Kim D.H. | * |
dc.contributor.scopusid | 허정원(7102258576) | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |