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약학대학
약학과
Journal papers
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Serotonin induces melanogenesis via serotonin receptor 2A
Title
Serotonin induces melanogenesis via serotonin receptor 2A
Authors
Lee H.J.
;
Park M.K.
;
Kim S.Y.
;
Park Choo H.Y.
;
Lee A.Y.
;
Lee C.H.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영
Issue Date
2011
Journal Title
British Journal of Dermatology
ISSN
0007-0963
Citation
British Journal of Dermatology vol. 165, no. 6, pp. 1344 - 1348
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Background Serotonin (5-hydroxytryptamine, 5-HT) levels are increased by light exposure but the role and mechanism of 5-HT in the pigmentation of skin cells are unclear. Objectives To clarify the effect of 5-HT on melanogenesis and to determine the 5-HT receptor subtype involved. Methods B16F10, SK-MEL-2 and Melan-A cells were cultured in Dulbecco's modified Eagle's medium with low fetal bovine serum. The three cell lines were treated with various concentrations of 5-HT, and 5-HT receptor agonists and antagonists. The involvement of the 5-HT receptor 2A (5-HTR2A) was examined by gene silencing and use of 5-HTR2A antagonists. Results 5-HT and the 5-HTR2A agonist, DOI, increased melanogenesis in the three cell lines. These increased events were suppressed by 5-HTR2A antagonists or gene silencing of the HTR2A gene. Conclusions 5-HTR2A is involved in melanogenesis. These findings highlight the role of 5-HT and suggest new ways of controlling melanogenesis. © 2011 British Association of Dermatologists 2011.
DOI
10.1111/j.1365-2133.2011.10490.x
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