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의과대학
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Journal papers
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Practical Synthesis and Biological Evaluation of Bergenin Analogs
Title
Practical Synthesis and Biological Evaluation of Bergenin Analogs
Authors
Jung J.-C.
;
Lim E.
;
Kim S.H.
;
Kim N.S.
;
Jung M.
;
Oh S.
Ewha Authors
오세관
;
정재철
SCOPUS Author ID
오세관
; 정재철
Issue Date
2011
Journal Title
Chemical Biology and Drug Design
ISSN
1747-0277
Citation
Chemical Biology and Drug Design vol. 78, no. 4, pp. 725 - 729
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
Here, we describe the practical synthesis and biological properties of bergenin and its structural analogs. Synthetic bergenin compounds were prepared by acylation of bergenin. These compounds were then evaluated for suppression of lipopolysaccharide-induced nitric oxide (NO) generation in cultured cells and anti-narcotic effects on morphine-dependent mice. We found that bergenin derivatives showed potent anti-inflammatory activity (suppression of NO generation) at concentrations ranging from 20 to 30μmin vitro, and bergenin derivatives (10-20mg/kg) exhibited significant anti-narcotic effects on morphine dependence in mice. These results suggest the potential utility of bergenin and its analogs as anti-narcotic agents and the design of more potent anti-inflammatory compounds. We have demonstrated simple and practical synthesis and evaluation of bergenin derivatives. It was found that the bergenin derivatives showed potent anti-inflammatory (suppressor of NO generation) with the concentration range 20-30μmin vitro, and bergenin derivatives (10-20mg/kg) exhibited significant anti-narcotic effect on morphine dependence in mice. © 2011 John Wiley & Sons A/S.
DOI
10.1111/j.1747-0285.2011.01194.x
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