Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-28T12:08:13Z | - |
dc.date.available | 2016-08-28T12:08:13Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 1051-0443 | * |
dc.identifier.other | OAK-7948 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221936 | - |
dc.description.abstract | Purpose: To evaluate the efficacy of an activin receptorlike kinase (ALK) 5 inhibitor, IN-1233, for the prevention of neointimal hyperplasia after bare stent placement in a rat common iliac artery (CIA) model. Materials and Methods: All experiments were approved by the committee of animal research. A self-expanding metallic bare stent (2 mm × 6 mm) was inserted into the left CIA of 26 Sprague-Dawley male rats (300360 g) under fluoroscopic guidance. IN-1233 was injected via the intraperitoneal route daily in 13 rats for 8 weeks after stent placement (group A); the other 13 rats underwent stent placement only (group B). Angiography was performed immediately and 4 weeks and 8 weeks after stent placement. Rats were sacrificed at 8 weeks after stent placement, and histologic findings were obtained. The neointimal area (NA), percentage of neointimal hyperplasia (%NH), and neointimal-to-medial area ratio (N/M) were assessed and compared between the two groups. Results: Stent placement was technically successful. In 25 rats, arteries with stent placement were angiographically patent, whereas 1 rat in group B had an occlusion. The NA (0.31 mm 2 ± 0.09 vs 0.56 mm 2 ± 0.17; P <.001), the %NH (26.16% ± 8.75 vs 44.71% ± 17.75; P <.001) and the N/M (1.93 ± 0.77 vs 4.77 ± 2.26; P <.001) were significantly decreased in group A compared with group B. Conclusions: IN-1233 was shown in this study to be effective for the prevention of neointimal hyperplasia after bare metallic stent placement in a rat CIA model. © 2011 SIR. | * |
dc.language | English | * |
dc.title | Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 22 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1321 | * |
dc.relation.lastpage | 1328 | * |
dc.relation.journaltitle | Journal of Vascular and Interventional Radiology | * |
dc.identifier.doi | 10.1016/j.jvir.2011.02.015 | * |
dc.identifier.wosid | WOS:000294592600016 | * |
dc.identifier.scopusid | 2-s2.0-80052028209 | * |
dc.author.google | Yoon H.-J. | * |
dc.author.google | Song H.-Y. | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Hong K.-S. | * |
dc.author.google | Kim Y.J. | * |
dc.author.google | Park H.G. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |