Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2016-08-28T12:08:49Z | - |
dc.date.available | 2016-08-28T12:08:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.other | OAK-7679 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221706 | - |
dc.description.abstract | In this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin-8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a C18 reverse phase HPLC column. By determination of its structure by MALDITOF and 1H- and 13C-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureusengulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection. | - |
dc.language | English | - |
dc.title | Adenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells | - |
dc.type | Article | - |
dc.relation.issue | 5 | - |
dc.relation.volume | 44 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 335 | - |
dc.relation.lastpage | 340 | - |
dc.relation.journaltitle | BMB Reports | - |
dc.identifier.doi | 10.5483/BMBRep.2011.44.5.335 | - |
dc.identifier.wosid | WOS:000291421900008 | - |
dc.identifier.scopusid | 2-s2.0-79958729117 | - |
dc.author.google | Ma Y.J. | - |
dc.author.google | Kim C.-H. | - |
dc.author.google | Ryu K.-H. | - |
dc.author.google | Kim M.-S. | - |
dc.author.google | So Y.-I. | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Garred P. | - |
dc.author.google | Lee B.-L. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |