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dc.contributor.author이공주*
dc.date.accessioned2016-08-28T12:08:49Z-
dc.date.available2016-08-28T12:08:49Z-
dc.date.issued2011*
dc.identifier.issn1976-6696*
dc.identifier.otherOAK-7679*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221706-
dc.description.abstractIn this study, we attempted to isolate novel mast cell-stimulating molecules from Staphylococcus aureus. Water-soluble extract of S. aureus cell lysate strongly induced human interleukin-8 in human mast cell line-1 and mouse interleukin-6 in mouse bone marrow-derived mast cells. The active molecule was purified to homogeneity through a C18 reverse phase HPLC column. By determination of its structure by MALDITOF and 1H- and 13C-NMR, adenosine was revealed to be responsible for the observed cytokine induction activities. Further studies using 8-sulfophenyl theophylline, a selective adenosine receptor blocker, verified that purified adenosine can induce interleukin-8 production via adenosine receptors on mast cells. Moreover, adenosine was purified from S. aureusengulfed RAW264.7 cells, a murine macrophage cell line, used to induce phagocytosis of S. aureus. These results show a novel view of the source of exogenous adenosine in vivo and provide a mechanistic link between inflammatory disease and bacterial infection.*
dc.languageEnglish*
dc.titleAdenosine derived from Staphylococcus aureus-engulfed macrophages functions as a potent stimulant for the induction of inflammatory cytokines in mast cells*
dc.typeArticle*
dc.relation.issue5*
dc.relation.volume44*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.indexKCI*
dc.relation.startpage335*
dc.relation.lastpage340*
dc.relation.journaltitleBMB Reports*
dc.identifier.doi10.5483/BMBRep.2011.44.5.335*
dc.identifier.wosidWOS:000291421900008*
dc.identifier.scopusid2-s2.0-79958729117*
dc.author.googleMa Y.J.*
dc.author.googleKim C.-H.*
dc.author.googleRyu K.-H.*
dc.author.googleKim M.-S.*
dc.author.googleSo Y.-I.*
dc.author.googleLee K.-J.*
dc.author.googleGarred P.*
dc.author.googleLee B.-L.*
dc.contributor.scopusid이공주(7501497635;57191532162)-
dc.date.modifydate20220804094732*
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약학대학 > 약학과 > Journal papers
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