Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신윤용 | * |
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-28T12:08:32Z | - |
dc.date.available | 2016-08-28T12:08:32Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-7498 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221561 | - |
dc.description.abstract | A series of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl) pyrazoles 14a-e, 15a-e, 17a-c, and 18a-d have been synthesized and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. The 6-quinolinyl pyrazole analogue 14b inhibited ALK5 phosphorylation with IC 50 value of 0.022 μM and showed 84% inhibition at 0.1 μM in a luciferase reporter assay using HaCaT cells permanently transfected with p3TP-luc reporter construct. © 2011 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin- 2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2633 | * |
dc.relation.lastpage | 2640 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2011.03.008 | * |
dc.identifier.wosid | WOS:000289281600016 | * |
dc.identifier.scopusid | 2-s2.0-79954425264 | * |
dc.author.google | Jin C.H. | * |
dc.author.google | Krishnaiah M. | * |
dc.author.google | Sreenu D. | * |
dc.author.google | Rao K.S. | * |
dc.author.google | Subrahmanyam V.B. | * |
dc.author.google | Park C.-Y. | * |
dc.author.google | Son J.-Y. | * |
dc.author.google | Sheen Y.Y. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 신윤용(6603872711) | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |