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Effect of different forms of anionic nanoclays on cytotoxicity
- Title
- Effect of different forms of anionic nanoclays on cytotoxicity
- Authors
- Baek M.; Kim I.-S.; Yu J.; Chung H.E.; Choy J.-H.; Choi S.-J.
- Ewha Authors
- 최진호
- SCOPUS Author ID
- 최진호
- Issue Date
- 2011
- Journal Title
- Journal of Nanoscience and Nanotechnology
- ISSN
- 1533-4880
- Citation
- Journal of Nanoscience and Nanotechnology vol. 11, no. 2, pp. 1803 - 1806
- Indexed
- SCIE; SCOPUS
- Document Type
- Conference Paper
- Abstract
- Anionic nanoclays, so-called layered double hydroxide (LDH) nanoparticles, have been extensively applied as drug delivery systems, since they efficiently enter cells via endocytosis pathway and possess controlled release property. However, the stability of LDHs varies, depending on the type of interlayer anions, which can also affect their toxicity. In this study, we investigated the effects of two different forms of LDH, carbonate form (MgAl-LDH-CO 3) and chloride form (MgAl-LDH-Cl), on cytotoxicity in human lung epithelial cells. The result showed that MgAl-LDH-Cl was more easily dissolved into metal ions under simulated lysosomal (pH 4.5) and body fluid (pH 7.4) conditions than did MgAl-LDH-CO 3. According to cytotoxicity evaluation, MgAl-LDH-CO 3 exhibited high toxicity compared with MgAl-LDH-Cl in terms of induction of oxidative stress, apoptosis and membrane damage. These results suggest that easily dissoluble MgAl-LDH-Cl has low cytotoxicity, while high Copyright © 2011 American Scientific Publishers All rights reserved stability of MgAl-LDH-CO 3 is correlated to elevated cytotoxicity. Copyright © 2011 American Scientific Publishers All rights reserved.
- DOI
- 10.1166/jnn.2011.3408
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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