Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정준모 | * |
dc.contributor.author | 노지현 | * |
dc.date.accessioned | 2016-08-28T12:08:12Z | - |
dc.date.available | 2016-08-28T12:08:12Z | - |
dc.date.issued | 2011 | * |
dc.identifier.issn | 0306-4522 | * |
dc.identifier.other | OAK-7302 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221380 | - |
dc.description.abstract | Despite the presence of Zn2+ in high levels in Parkinson brain, it is not yet clearly answered whether and how Zn2+ alters the electrical activity of neurons in substantia nigra (SN). Here we show that Zn2+ alters the intrinsic activity of nigral dopamine neurons in dual ways, that is, excitation or inhibition, by modulating the gating properties of a transient A-type K+ (KA) channel. Depending on the holding potential, Zn2+ could reduce or enhance a transient outward K+ current (IA) in nigral dopamine neurons. Zn2+ slowed the kinetics of both IA activation and inactivation with the rate of activation much more reduced than that of inactivation. Zn2+ also increased the rate of release from IA inactivation. Both activation and inactivation IA curves were shifted by Zn2+ towards positive potentials, but the positive shift of the inactivation curve was much greater than that of the activation curve. We propose that all these effects of Zn2+ on KA channel gating properties underlie the dual mode of Zn2+ action on IA, that is, attenuation or potentiation depending on membrane potential. As a result, Zn2+ increased a bursting activity of a nigral dopamine neuron elicited by anodal break excitation presumably through IA reduction at a hyperpolarizing state, whereas Zn2+ decreased its tonic activity at either resting or depolarizing states where IA was increased. This was further supported by the observations that 4-aminopyridine (4-AP), a well-known KA channel blocker, strengthened or counteracted the effect of Zn2+ on the intrinsic excitability of nigral dopamine neurons. © 2011 IBRO. | * |
dc.language | English | * |
dc.title | Dual function of Zn2+ on the intrinsic excitability of dopaminergic neurons in rat substantia nigra | * |
dc.type | Article | * |
dc.relation.volume | 175 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 85 | * |
dc.relation.lastpage | 92 | * |
dc.relation.journaltitle | Neuroscience | * |
dc.identifier.doi | 10.1016/j.neuroscience.2010.11.019 | * |
dc.identifier.wosid | WOS:000287106300008 | * |
dc.identifier.scopusid | 2-s2.0-78951490770 | * |
dc.author.google | Noh J. | * |
dc.author.google | Chang S.Y. | * |
dc.author.google | Wang S.Y. | * |
dc.author.google | Chung J.M. | * |
dc.contributor.scopusid | 정준모(9233608000) | * |
dc.contributor.scopusid | 노지현(7102906083) | * |
dc.date.modifydate | 20240415121825 | * |