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dc.contributor.author정익모-
dc.date.accessioned2016-08-28T12:08:58Z-
dc.date.available2016-08-28T12:08:58Z-
dc.date.issued2010-
dc.identifier.issn0167-5273-
dc.identifier.otherOAK-7118-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221224-
dc.description.abstractBackground: Extracellular matrix (ECM) accumulation significantly contributes to in-stent restenosis. In this regard, transforming growth factor (TGF)-β, a positive regulator of ECM deposition, may be implicated in in-stent restenosis. The goal of this study was to assess the effect of blockade of TGF-β on stent-induced restenosis in porcine coronary arteries. Methods: An adenovirus expressing the ectodomain of the TGF-β type II receptor (AdTβ-ExR) was applied onto a coronary arterial segment of a pig (n = 10) using an Infiltrator TM, followed by stent deployment. Controls consisted of adenoviruses expressing β-galactosidase (AdLacZ) or phosphate-buffered saline (PBS) applied onto the other segment (n = 10) of the same pig. Results: Computer-based pathological morphometric analysis of stented coronary arteries, performed 4 weeks after stenting, demonstrated no significant difference in morphometric parameters such as in-stent neointimal area and % area stenosis between the AdTβ-ExR group and control (n = 7 for each). However the AdTβ-ExR group had increased neointimal cell density, infiltration of inflammatory cells mostly consisting of CD3 + T cell, accumulation of hyaluronan, cell proliferation rate, and adventitial matrix metalloproteinase-1 (MMP-1) expression compared with control. The expression of connective tissue growth factor mRNA, measured by reverse transcription PCR, in cultured rat arterial smooth muscle cells was inhibited by AdTβ-ExR at moi 60. Conclusions: Blockade of TGF-β by catheter-based local intravascular gene delivery does not reduce stent-induced neointima formation 4 weeks after stenting in spite of modest inhibition of ECM accumulation, but it induces vascular inflammation and associated pathological changes that may potentially aggravate lesion progression. © 2009 Elsevier Ireland Ltd.-
dc.languageEnglish-
dc.titleBlockade of TGF-β by catheter-based local intravascular gene delivery does not alter the in-stent neointimal response, but enhances inflammation in pig coronary arteries-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume145-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage468-
dc.relation.lastpage475-
dc.relation.journaltitleInternational Journal of Cardiology-
dc.identifier.doi10.1016/j.ijcard.2009.11.032-
dc.identifier.wosidWOS:000285136200025-
dc.identifier.scopusid2-s2.0-78149349800-
dc.author.googleChung I.-M.-
dc.author.googleKim J.-
dc.author.googlePak Y.K.-
dc.author.googleJang Y.-
dc.author.googleYang W.-I.-
dc.author.googleHan I.-
dc.author.googlePark S.-J.-
dc.author.googlePark S.-W.-
dc.author.googleHuh J.-
dc.author.googleWight T.N.-
dc.author.googleUeno H.-
dc.contributor.scopusid정익모(7201867918)-
dc.date.modifydate20180329110645-
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의과대학 > 의학과 > Journal papers
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