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dc.contributor.author김영석-
dc.date.accessioned2016-08-28T12:08:57Z-
dc.date.available2016-08-28T12:08:57Z-
dc.date.issued2011-
dc.identifier.issn0308-8146-
dc.identifier.otherOAK-7104-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221213-
dc.description.abstractThe antiproliferative activities of the chloroform fraction (CF) of guava (Psidium cattleianum Sabine) leaf extract were evaluated using several cancer cell lines. Maximum cytotoxicity was observed in SNU-16, a human gastric carcinoma cell line, at concentrations of 50-100 μg/ml. Flow cytometric analysis demonstrated that CF treatment resulted in a marked accumulation of SNU-16 cells in the sub-G1 phase at concentrations of 100-200 μg/ml. The induction of apoptosis in SNU-16 cells was confirmed by immunoblotting using antibodies against Bcl-2, Bax, poly (ADP-ribose) polymerase (PARP), caspase-8, and caspase-3. The major CF phytochemicals were identified as ferulic acid, genistein, 3′, 4′, 5′ trimethoxy flavone, phlorizin, and oleanolic acid by high performance liquid chromatography coupled with a photo diode array and electrospray ionisation mass spectrometry (HPLC-PDA-ESI-MS). The results suggest that phytochemicals in the CF of guava (P. cattleianum) leaf extract induce apoptosis in SNU-16 cells. These findings may lead to new strategies for treating human gastric cancer. © 2010 Elsevier Ltd.-
dc.languageEnglish-
dc.titleThe chloroform fraction of guava (Psidium cattleianum sabine) leaf extract inhibits human gastric cancer cell proliferation via induction of apoptosis-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume125-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage369-
dc.relation.lastpage375-
dc.relation.journaltitleFood Chemistry-
dc.identifier.doi10.1016/j.foodchem.2010.09.007-
dc.identifier.wosidWOS:000284975200011-
dc.identifier.scopusid2-s2.0-78049423971-
dc.author.googleMoon J.Y.-
dc.author.googleMosaddik A.-
dc.author.googleKim H.-
dc.author.googleCho M.-
dc.author.googleChoi H.-K.-
dc.author.googleKim Y.S.-
dc.author.googleCho S.K.-
dc.contributor.scopusid김영석(56155360400)-
dc.date.modifydate20170922131527-
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엘텍공과대학 > 식품공학전공 > Journal papers
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