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dc.contributor.author편욱범-
dc.date.accessioned2016-08-28T12:08:54Z-
dc.date.available2016-08-28T12:08:54Z-
dc.date.issued2010-
dc.identifier.issn1064-1963-
dc.identifier.otherOAK-7070-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221182-
dc.description.abstractRegression of left ventricular (LV) hypertrophy (LVH) is known to be related to a lower incidence of stroke in hypertensive patients with nonvalvular atrial fibrillation (NV-AF). However, its mechanism remains controversial. Recently, diastolic dysfunction (DD) was reported to be correlated with ischemic stroke in NV-AF. We hypothesized that hypertension (HTN) and resultant LVH might be associated with the severity of DD in NV-AF. Two hundred and ninety-four patients (204 males, age 66 ± 12 y) with NV-AF with preserved LV systolic function were included. Clinical and echocardiographic data were compared between patients with enlarged left atrial (LA) volume (n = 237) and patients with normal LA. Age (60 ± 12 vs. 67 ± 11 years), sex (male; 81 vs. 62%), duration of NV-AF (4.1 ± 7.8 vs. 45.7 ± 49.0 months), brain natriuretic peptide (108.3 ± 129.3 vs. 236.1 ± 197.0 pg/mL), right ventricular systolic pressure (24.5 ± 5.5 vs. 33.1 ± 11.1 mmHg), mitral inflow velocity (E [77.4 ± 22.2 vs. 88.3 ± 22.0 cm/s]), LV mass index (LVMI [87.6 ± 22.2 vs. 105.1 ± 23.2 g/m2]), peak systolic mitral annular velocity (S' [7.2 ± 2.0 vs. 5.8 ± 1.8 cm/s]), and mitral inflow velocity to diastolic mitral annular velocity (E/E' [9.8 ± 3.4 vs. 12.1 ± 4.4]) were significantly different between the two groups, respectively (P < 0.05). In multivariate analysis, LVMI was independently correlated with increased LA volume (OR: 1.037 [95% CI: 1.011-1.063], P < 0.05), whereas HTN was not. LA enlargement, which reflects the severity and chronicity of DD, is independently associated with LVH in patients with NV-AF. Therefore, regression of LVH with anti-hypertensive treatment may lead to improvement of diastolic function and favorable clinical outcomes in hypertensive patients with NV-AF. © 2010 Informa Healthcare USA, Inc.-
dc.languageEnglish-
dc.titleLeft ventricular hypertrophy determines the severity of diastolic dysfunction in patients with nonvalvular atrial fibrillation and preserved left ventricular systolic function-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume32-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage540-
dc.relation.lastpage546-
dc.relation.journaltitleClinical and Experimental Hypertension-
dc.identifier.doi10.3109/10641963.2010.496522-
dc.identifier.wosidWOS:000284541100007-
dc.identifier.scopusid2-s2.0-79251511256-
dc.author.googleMoon J.-
dc.author.googleRim S.-J.-
dc.author.googleCho I.J.-
dc.author.googleLee S.-H.-
dc.author.googleChoi S.-
dc.author.googleChung W.-J.-
dc.author.googleByun Y.-S.-
dc.author.googleRyu S.-K.-
dc.author.googlePyun W.-B.-
dc.author.googleKim J.-Y.-
dc.contributor.scopusid편욱범(6508352922)-
dc.date.modifydate20180329112529-
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의과대학 > 의학과 > Journal papers
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