Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이병구 | - |
dc.date.accessioned | 2016-08-28T12:08:53Z | - |
dc.date.available | 2016-08-28T12:08:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.other | OAK-7054 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221168 | - |
dc.description.abstract | Protoberberine isoquinoline alkaloids including berberine inhibit dopamine biosynthesis and aggravate l-DOPA-induced cytotoxicity in PC12 cells. In this study, the effects of berberine on 6-hydroxydopamine (6-OHDA)-induced cytotoxicity in PC12 cells and on unilateral 6-OHDA-lesioned rats were investigated. In PC12 cells, berberine at 10 and 30 μM associated with 6-OHDA (10, 20, and 50 μM) enhanced cytotoxicity at 48. h compared to 6-OHDA alone, indicated by an increase in apoptotic cell death. In addition, treatment with berberine (5 and 30. mg/kg, i.p.) for 21 days in 6-OHDA-lesioned rats markedly depleted tyrosine hydroxylase-immunopositive cells in the substantia nigra as compared to berberine-untreated rats. Further, the levels of dopamine and norepinephrine were also significantly decreased by berberine administration (5 and 30. mg/kg) in the striatal regions of 6-OHDA-lesioned rats. These results suggested that berberine aggravated 6-OHDA-induced cytotoxicity in PC12 cells, and led to the degeneration of dopaminergic neuronal cells in the substantia nigra of 6-OHDA-lesioned rats. It is, therefore, suggested that the use of long-term l-DOPA therapy with isoquinoline derivatives including berberine may need to be examined for the presence of adverse symptoms. © 2010 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Effects of berberine on 6-hydroxydopamine-induced neurotoxicity in PC12 cells and a rat model of Parkinson's disease | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 486 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 29 | - |
dc.relation.lastpage | 33 | - |
dc.relation.journaltitle | Neuroscience Letters | - |
dc.identifier.doi | 10.1016/j.neulet.2010.09.038 | - |
dc.identifier.wosid | WOS:000284293200007 | - |
dc.identifier.scopusid | 2-s2.0-77957892635 | - |
dc.author.google | Kwon I.H. | - |
dc.author.google | Choi H.S. | - |
dc.author.google | Shin K.S. | - |
dc.author.google | Lee B.K. | - |
dc.author.google | Lee C.K. | - |
dc.author.google | Hwang B.Y. | - |
dc.author.google | Lim S.C. | - |
dc.author.google | Lee M.K. | - |
dc.contributor.scopusid | 이병구(55502906900;55758384300) | - |
dc.date.modifydate | 20220119161839 | - |