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dc.contributor.author이공주-
dc.contributor.author신동해-
dc.date.accessioned2016-08-28T12:08:50Z-
dc.date.available2016-08-28T12:08:50Z-
dc.date.issued2010-
dc.identifier.issn1744-3091-
dc.identifier.otherOAK-7023-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221142-
dc.description.abstractNucleoside diphosphate kinase (NDPK) catalyzes transfer of the - phosphoryl group from a nucleoside triphosphate (NTP) to a nucleoside diphosphate. The high-energy phosphate for this reaction is usually supplied by ATP. NDPK plays a primary role not only in maintaining cellular pools of all NTPs but also in the regulation of important cellular processes. NDPK-A (or Nm23-H1), one of eight human NDPKs, acts as a metastasis suppressor for some tumour types. A recent study showed that homohexameric human NDPK-A is regulated in response to oxidative stress. The activity of NDPK-A is reduced, with a concomitant increase in the population of dimeric NDPK-A, under oxidative conditions. In this study, human NDPK-A has been crystallized under oxidative conditions and X-ray data have been collected to 2.80 Å resolution using synchrotron radiation. The crystal belonged to the primitive cubic space group P213, with unit-cell parameters a = b = c = 106.8 Å. There is one NDPK-A dimer in the asymmetric unit. The preliminary electron-density map shows a large conformational change of the C-terminal domain of NDPK-A induced by a novel disulfide bond that is formed under oxidative conditions. © 2010 International Union of Crystallography All rights reserved.-
dc.languageEnglish-
dc.titleA preliminary X-ray study of human nucleoside diphosphate kinase A under oxidative conditions-
dc.typeConference Paper-
dc.relation.issue11-
dc.relation.volume66-
dc.relation.indexSCOPUS-
dc.relation.startpage1490-
dc.relation.lastpage1492-
dc.relation.journaltitleActa Crystallographica Section F: Structural Biology and Crystallization Communications-
dc.identifier.doi10.1107/S1744309110036067-
dc.identifier.wosidWOS:000283714100021-
dc.identifier.scopusid2-s2.0-78149318712-
dc.author.googleKim M.-S.-
dc.author.googleJeong J.-
dc.author.googleLee K.-J.-
dc.author.googleShin D.H.-
dc.contributor.scopusid이공주(7501497635)-
dc.contributor.scopusid신동해(57217374185;15920079700)-
dc.date.modifydate20211116101047-
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약학대학 > 약학과 > Journal papers
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