Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최진호 | - |
dc.contributor.author | 박명철 | - |
dc.date.accessioned | 2016-08-28T12:08:48Z | - |
dc.date.available | 2016-08-28T12:08:48Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0959-9428 | - |
dc.identifier.other | OAK-6995 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221119 | - |
dc.description.abstract | A methotrexate (MTX)-layered double hydroxide (LDH) hybrid have been developed as a drug delivery system, in which an anticancer drug, MTX, was intercalated into a 2-dimensional LDH nanovehicle to form a nanohybrid. According to the comparative cell viability studies between MTX only and its LDH nanohybrid on MTX sensitive and resistant cell culture lines, it was found that the MTX-LDH nanohybrid could bypass the MTX resistance and eventually inhibit cancer cell proliferation very effectively compared to free MTX, due to an enhanced permeability and retention effect of MTX-LDH nanoparticles even in dihydrofolate reductase-overexpressing MTX-resistant cells. This is definitely associated with the uptake mechanism via a clathrin-mediated endocytic pathway for the MTX-LDH nanohybrid particles, the same as for the LDH nanocarrier only, which is completely different from the cellular uptake mechanism for MTX only, the reduced folate carrier (RFC) and/or the folate receptor entries. © 2010 The Royal Society of Chemistry. | - |
dc.language | English | - |
dc.title | Anticancer drug encapsulated in inorganic lattice can overcome drug resistance | - |
dc.type | Article | - |
dc.relation.issue | 42 | - |
dc.relation.volume | 20 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 9463 | - |
dc.relation.lastpage | 9469 | - |
dc.relation.journaltitle | Journal of Materials Chemistry | - |
dc.identifier.doi | 10.1039/b925831k | - |
dc.identifier.wosid | WOS:000283264500023 | - |
dc.identifier.scopusid | 2-s2.0-78049255413 | - |
dc.author.google | Choi S.-J. | - |
dc.author.google | Choi G.E. | - |
dc.author.google | Oh J.-M. | - |
dc.author.google | Oh Y.-J. | - |
dc.author.google | Park M.-C. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.contributor.scopusid | 박명철(56319349700) | - |
dc.date.modifydate | 20230530111656 | - |