Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최정윤 | - |
dc.date.accessioned | 2016-08-28T12:08:47Z | - |
dc.date.available | 2016-08-28T12:08:47Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1528-7394 | - |
dc.identifier.other | OAK-6981 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221106 | - |
dc.description.abstract | The toxicity of formaldehyde (HCHO) has been attributed to its ability to form adducts with DNA and proteins. Triphlorethol-A, derived from Ecklonia cava, was reported to exert a cytoprotective effect against oxidative stress damage via an antioxidant mechanism. The aim of this study was to examine the mechanisms underlying the triphlorethol-A ability to protect Chinese hamster lung fibroblast (V79-4) cells against HCHO-induced damage. Triphlorethol-A significantly decreased the HCHO-induced intracellular reactive oxygen species (ROS) production. Triphlorethol-A prevented increased cell damage induced by HCHO via inhibition of mitochondria-mediated caspase-dependent apoptosis pathway. Triphlorethol-A diminished HCHO-induced mitochondrial dysfunction, including loss of mitochondrial membrane action potential (Δψ) and adenosine triphosphate (ATP) depletion. Furthermore, the anti-apoptotic effect of triphlorethol-A was exerted through inhibition of c-Jun NH 2-terminal kinase (JNK), which was enhanced by HCHO. Our data indicate that triphlorethol-A exerts a cytoprotective effect in V79-4 cells against HCHO-induced oxidative stress by inhibiting the mitochondria-mediated caspase-dependent apoptotic pathway. Copyright © Taylor & Francis Group, LLC. | - |
dc.language | English | - |
dc.title | Cytoprotective effects of triphlorethol-A against formaldehyde-induced oxidative damage and apoptosis: Role of mitochondria-mediated caspase-dependent pathway | - |
dc.type | Article | - |
dc.relation.issue | 21-22 | - |
dc.relation.volume | 73 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1477 | - |
dc.relation.lastpage | 1489 | - |
dc.relation.journaltitle | Journal of Toxicology and Environmental Health - Part A: Current Issues | - |
dc.identifier.doi | 10.1080/15287394.2010.511564 | - |
dc.identifier.wosid | WOS:000282974000007 | - |
dc.identifier.scopusid | 2-s2.0-77958160054 | - |
dc.author.google | Zhang R. | - |
dc.author.google | Lee I.K. | - |
dc.author.google | Kang K.A. | - |
dc.author.google | Piao M.J. | - |
dc.author.google | Kim K.C. | - |
dc.author.google | Kim B.J. | - |
dc.author.google | Lee N.H. | - |
dc.author.google | Choi J.-Y. | - |
dc.author.google | Choi J. | - |
dc.author.google | Hyun J.W. | - |
dc.contributor.scopusid | 최정윤(57223660142;34973862000) | - |
dc.date.modifydate | 20230627091252 | - |