Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김승철 | - |
dc.contributor.author | 주웅 | - |
dc.contributor.author | 이사라 | - |
dc.date.accessioned | 2016-08-28T12:08:43Z | - |
dc.date.available | 2016-08-28T12:08:43Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 2005-0380 | - |
dc.identifier.other | OAK-6929 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221067 | - |
dc.description.abstract | Objective: The goal of this study was to investigate the relationship between plasma levels of insulin-like growth factors-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) and the risk for cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: Plasma levels of IGF-1 and IGFBP-3 of 44 cervical cancer patients, 82 CIN patients and 40 neoplasm-free patients were investigated. Then the associations of the plasma levels of IGF-1 and IGFBP-3 with cervical neoplasm or its clinicopathologic parameters were analyzed. Results: The mean IGF-1 concentrations were significantly different among the control, CIN, and cervical cancer groups; the levels were higher in the CIN group compared to the controls. According to the quartile category, the plasma IGF-1 level was significantly higher (p=0.0015) in the CIN group than in the controls. The IGFBP-3 level showed no association between the controls and CIN groups (p=0.842). Although the mean IGF-1/IGFBP-3 molar ratio had borderline significance (p=0.08) among the study population, the quartile comparison showed a significantly higher IGF-1/IGFBP-3 molar ratio in the CIN group compared to the control group (p=0.041). Conclusion: Plasma levels of IGF-1 and the IGF-1/IGFBP-3 molar ratio might be useful for the development early detection of cervical lesions and used as an adjuvant diagnostic tool for cervical neoplasia after more larger scale research. | - |
dc.language | English | - |
dc.title | Plasma levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in women with cervical neoplasia | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 174 | - |
dc.relation.lastpage | 180 | - |
dc.relation.journaltitle | Journal of Gynecologic Oncology | - |
dc.identifier.doi | 10.3802/jgo.2010.21.3.174 | - |
dc.identifier.wosid | WOS:000282303800006 | - |
dc.identifier.scopusid | 2-s2.0-78049452917 | - |
dc.author.google | Lee S.W. | - |
dc.author.google | Lee S.Y. | - |
dc.author.google | Lee S.R. | - |
dc.author.google | Ju W. | - |
dc.author.google | Kim S.C. | - |
dc.contributor.scopusid | 김승철(35264000100) | - |
dc.contributor.scopusid | 주웅(8873659700) | - |
dc.contributor.scopusid | 이사라(17343827300) | - |
dc.date.modifydate | 20230210135401 | - |