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dc.contributor.author윤여준-
dc.contributor.author박제원-
dc.date.accessioned2016-08-28T12:08:43Z-
dc.date.available2016-08-28T12:08:43Z-
dc.date.issued2010-
dc.identifier.issn1017-7825-
dc.identifier.otherOAK-6925-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/221064-
dc.description.abstractRecently, recombinant Streptomyces venezuelae has been established as a heterologous host for microbial production of flavanones and stilbenes, a class of plant-specific polyketides. In the present work, we expanded the applicability of the S. venezuelae system to the production of more diverse plant polyketides including flavones and flavonols. A plasmid with the synthetic codon-optimized flavone synthase I gene from Petroselium crispum was introduced to S. venezuelae DHS2001 bearing a deletion of the native pikromycin polyketide synthase gene, and the resulting strain generated flavones from exogenously fed flavanones. In addition, a recombinant S. venezuelae mutant expressing a codon-optimized flavanone 3β-hydroxylase gene from Citrus siensis and a flavonol synthase gene from Citrus unshius also successfully produced flavonols.-
dc.languageEnglish-
dc.titleBiosynthesis of plant-specific flavones and flavonols in Streptomyces venezuelae-
dc.typeArticle-
dc.relation.issue9-
dc.relation.volume20-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage1295-
dc.relation.lastpage1299-
dc.relation.journaltitleJournal of Microbiology and Biotechnology-
dc.identifier.doi10.4014/jmb.1005.05038-
dc.identifier.wosidWOS:000282260500006-
dc.identifier.scopusid2-s2.0-77957741042-
dc.author.googlePark S.R.-
dc.author.googlePaik J.H.-
dc.author.googleAhn M.S.-
dc.author.googlePark J.W.-
dc.author.googleYoon Y.J.-
dc.contributor.scopusid윤여준(7402126465)-
dc.date.modifydate20210708161345-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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