Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:38Z | - |
dc.date.available | 2016-08-28T12:08:38Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0223-5234 | * |
dc.identifier.other | OAK-6854 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221016 | - |
dc.description.abstract | In order to develop potential anti-cancer agents that act on topoisomerase II and DNA, we have synthesized 12 new xanthone derivatives. In the cytotoxicity test, compounds 17 and 31 exhibited 2- to 7-fold stronger inhibitory activity than adriamycin against most cancer cell lines tested. Halohydrin group-tethered compounds 19, 21 and 27 showed comparable topoisomerase II inhibitory activity to etoposide at 100 μM concentration. In the DNA cross-linking test, compounds 20, 30 and 31 produced DNA cross-linked adducts and compound 30 was the strongest DNA cross-linker. Based on the combined pharmacological results, we suspected that the strong anti-cancer activity of compounds 16, 17, 20, 30 and 31 originated from the DNA mono-alkylation or cross-linking properties of the compounds. In order to develop potential anti-cancer agents that act on topoisomerase II and DNA, we have synthesized 12 new xanthone derivatives. © 2010 Elsevier Masson SAS. All rights reserved. | * |
dc.language | English | * |
dc.title | Synthesis and pharmacological evaluation of new methyloxiranylmethoxyxanthone analogues | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 45 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4221 | * |
dc.relation.lastpage | 4228 | * |
dc.relation.journaltitle | European Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.ejmech.2010.06.017 | * |
dc.identifier.wosid | WOS:000281568600086 | * |
dc.identifier.scopusid | 2-s2.0-77955551433 | * |
dc.author.google | Woo S. | * |
dc.author.google | Kang D.-H. | * |
dc.author.google | Nam J.M. | * |
dc.author.google | Lee C.S. | * |
dc.author.google | Ha E.-M. | * |
dc.author.google | Lee E.-S. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Na Y. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240123101932 | * |