Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 이화정 | * |
dc.date.accessioned | 2016-08-28T12:08:38Z | - |
dc.date.available | 2016-08-28T12:08:38Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1612-1872 | * |
dc.identifier.other | OAK-6843 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221010 | - |
dc.description.abstract | The aim of the present study was to investigate the effects of di- and sesquiterpenoids isolated from the pods of Sindora sumatranaMiq. (Leguminosae) on P-glycoprotein (P-gp) function in an adriamycin-resistant human breast cancer cell line, MCF-7/ADR. Over-expression of P-gp is known to be one of the mechanisms involved in multidrug resistance (MDR), which is a major obstacle in clinical cancer treatment. Among six di- and sesquiterpenoids extracted from S. sumatrana, (+)-7β-acetoxy-15,16-epoxycleroda-3,13(16),14-trien-18-oic acid (1) showed a strong P-gp inhibitory effect, as great as that of verapamil, a representative P-gp inhibitor. Compound 1 enhanced daunomycin accumulation more than fourfold and significantly decreased daunomycin efflux compared with control, resulting in a decrease in the IC50 value for daunomycin. These results suggest that compound 1 inhibits the functioning of P-gp and, therefore, can be developed as an MDR-reversing agent. © 2010 Verlag Helvetica Chimica Acta AG. | * |
dc.language | English | * |
dc.title | Inhibition of P-glycoprotein-induced multidrug resistance by a clerodane-type diterpenoid from Sindora sumatrana | * |
dc.type | Article | * |
dc.relation.issue | 8 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 2095 | * |
dc.relation.lastpage | 2101 | * |
dc.relation.journaltitle | Chemistry and Biodiversity | * |
dc.identifier.doi | 10.1002/cbdv.201000010 | * |
dc.identifier.wosid | WOS:000281489400021 | * |
dc.identifier.scopusid | 2-s2.0-77956207552 | * |
dc.author.google | Jung H.J. | * |
dc.author.google | Chung S.Y. | * |
dc.author.google | Nam J.-W. | * |
dc.author.google | Chae S.W. | * |
dc.author.google | Lee Y.-J. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee H.J. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 이화정(57102029300) | * |
dc.date.modifydate | 20240118144717 | * |