Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | - |
dc.contributor.author | 임선희 | - |
dc.date.accessioned | 2016-08-28T12:08:38Z | - |
dc.date.available | 2016-08-28T12:08:38Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1523-0864 | - |
dc.identifier.other | OAK-6841 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/221008 | - |
dc.description.abstract | Limited amounts of reactive oxygen species are necessary for cell survival and signaling, but their excess causes oxidative stress. H2O 2 and other reactive oxygen species are formed as byproducts of several metabolic pathways, possibly including oxidative protein folding in the endoplasmic reticulum. B-to plasma-cell differentiation is characterized by a massive expansion of the endoplasmic reticulum, finalized to sustain abundant immunoglobulin (Ig) synthesis and secretion. The increased production of disulfide-rich Ig might cause oxidative stress that could serve signaling roles in the differentiation and lifespan control of antibody-secreting cells. Here we show that terminal B-cell differentiation entails redox stress, NF-E2-related factor-2 (Nrf2) activation, and reshaping of the antioxidant responses. However, plasma-cell differentiation was not dramatically impaired in peroxiredoxin (Prx)1-, 2-, 3-, and 4-, glutathione peroxidase 1-, and Nrf2-knockout splenocytes, suggesting redundancy and robustness in antioxidant systems. Endoplasmic reticulum (ER)-resident Prx4 increases dramatically during differentiation. In its absence, IgM secretion was not significantly affected, but more high-molecular-weight covalent complexes accumulated intracellularly. Our results suggest that the early intracellular production of H 2O2 facilitates B-cell proliferation and reveal a role for the Nrf2 pathway in the differentiation and function of IgM-secreting cells. © 2010, Mary Ann Liebert, Inc. | - |
dc.language | English | - |
dc.title | B-to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1133 | - |
dc.relation.lastpage | 1144 | - |
dc.relation.journaltitle | Antioxidants and Redox Signaling | - |
dc.identifier.doi | 10.1089/ars.2009.3079 | - |
dc.identifier.wosid | WOS:000281480200001 | - |
dc.identifier.scopusid | 2-s2.0-77956301804 | - |
dc.author.google | Bertolotti M. | - |
dc.author.google | Yim S.H. | - |
dc.author.google | Garcia-Manteiga J.M. | - |
dc.author.google | Masciarelli S. | - |
dc.author.google | Kim Y.-J. | - |
dc.author.google | Kang M.-H. | - |
dc.author.google | Iuchi Y. | - |
dc.author.google | Fujii J. | - |
dc.author.google | Vene R. | - |
dc.author.google | Rubartelli A. | - |
dc.author.google | Rhee S.G. | - |
dc.author.google | Sitia R. | - |
dc.contributor.scopusid | 이서구(7401852092) | - |
dc.contributor.scopusid | 임선희(56511253000) | - |
dc.date.modifydate | 20230630140641 | - |