Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-08-28T12:08:34Z | - |
dc.date.available | 2016-08-28T12:08:34Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.other | OAK-6800 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220975 | - |
dc.description.abstract | Aim of this study: GCSB-5 is a traditional medicine preparation composed with six oriental herbs which have been widely used for the inflammatory diseases in Asia. In the present study, we have demonstrated the anti-inflammatory effects of GCSB-5 in vivo and in vitro along with its underlying mechanism of action. Methods: The acute and chronic inflammation models in animals were applied to investigate the anti-inflammatory effects of GCSB-5. To further investigate the mechanism of the anti-inflammatory activity, lipopolysaccharide (LPS)-induced murine macrophage RAW264.7 cells were also employed. Results: In in vivo animal model, oral administration of GCSB-5 significantly inhibited TPA- and carrageenan-induced acute edema and adjuvant-induced arthritis. The vascular permeability, leukocyte migration, and granuloma formation were also inhibited by GCSB-5. In accordance, GCSB-5 suppressed the LPS-induced nitric oxide (NO) production by the downregulation of mRNA and protein expressions of inducible nitric oxide synthase (iNOS). GCSB-5 also suppressed the expressions of cyclooxygenase-2 (COX-2) and inflammatory cytokines such as interleukin-1β and interferon-β. The activation of NF-κB by LPS was also alleviated by GCSB-5, which correlated with its inhibitory effect on IkB degradation. The signaling pathway with the activation of Akt was also attenuated by the treatment by GCSB-5. Conclusions: Taken together, our results demonstrate that GCSB-5 reduces the development of acute and chronic inflammation and its anti-inflammatory property might in part be a function of the inhibition of iNOS and COX-2 expression via down-regulation of the Akt signal pathway and inhibition of NF-κB activation. These findings suggest that GCSB-5 might be an applicable therapeutic traditional medicine in the regulation of the inflammatory response. © 2010 Elsevier Ireland Ltd. | - |
dc.language | English | - |
dc.title | Modulation of acute and chronic inflammatory processes by a traditional medicine preparation GCSB-5 both in vitro and in vivo animal models | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 130 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 450 | - |
dc.relation.lastpage | 459 | - |
dc.relation.journaltitle | Journal of Ethnopharmacology | - |
dc.identifier.doi | 10.1016/j.jep.2010.05.020 | - |
dc.identifier.wosid | WOS:000280869900002 | - |
dc.identifier.scopusid | 2-s2.0-77954952397 | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Lee H.-S. | - |
dc.author.google | Shin J.-S. | - |
dc.author.google | Lee S.-H. | - |
dc.author.google | Park B.-M. | - |
dc.author.google | Youn Y.-S. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |