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dc.contributor.author김영주-
dc.date.accessioned2016-08-28T12:08:31Z-
dc.date.available2016-08-28T12:08:31Z-
dc.date.issued2010-
dc.identifier.issn0015-0282-
dc.identifier.otherOAK-6765-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220946-
dc.description.abstractObjective: To assess whether the differential sperm tail swelling patterns observed following hypo-osmotic shock are useful in discriminating normal sperm from aneuploid sperm. Design: Prospective study. Setting: University research setting. Intervention(s): Fluorescence in situ hybridization (FISH) was combined with hypo-osmotic swelling for a simultaneous assessment of aneuploidy and viability in human spermatozoa. Main Outcome Measure(s): FISH for chromosomes 1, 13, 18, 21, X, and Y after hypo-osmotic stress was used to investigate the distribution of sperm aneuploidy related to sperm-tail swelling patterns. A total of 16,473 sperm cells were scored from three normal fertile donors and six oligoasthenoteratozoospermic (OAT) patients. Result(s): There was a 17.2-fold decrease in the frequency of total aneuploidy in the sperm with a tail-tip swelling pattern compared with the initial nonselected sperm in the OAT patients. Strikingly, when the sperm with tail-tip swelling patterns were screened from the patients, the frequency of total aneuploidy was actually lower by a factor of four than in the nonselected sperm from fertile donors. Conclusion(s): The sperm cells with tail-tip swelling patterns are related to a low frequency of aneuploidy. © 2010 by American Society for Reproductive Medicine.-
dc.languageEnglish-
dc.titleNumerical chromosome abnormalities are associated with sperm tail swelling patterns-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume94-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1012-
dc.relation.lastpage1020-
dc.relation.journaltitleFertility and Sterility-
dc.identifier.doi10.1016/j.fertnstert.2009.04.043-
dc.identifier.wosidWOS:000280407900028-
dc.identifier.scopusid2-s2.0-77955586683-
dc.author.googlePang M.-G.-
dc.author.googleYou Y.-A.-
dc.author.googlePark Y.-J.-
dc.author.googleOh S.-A.-
dc.author.googleKim D.-S.-
dc.author.googleKim Y.-J.-
dc.contributor.scopusid김영주(55801681000)-
dc.date.modifydate20180329110514-
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의과대학 > 의학과 > Journal papers
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