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dc.contributor.author정성애-
dc.date.accessioned2016-08-28T12:08:28Z-
dc.date.available2016-08-28T12:08:28Z-
dc.date.issued2010-
dc.identifier.issn1043-4666-
dc.identifier.otherOAK-6735-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220922-
dc.description.abstractHelicobacter pylori (H. pylori) is an important risk factor of gastric adenocarcinoma. Interleukin (IL)-8 is a potent angiogenic factor and plays an important role in inflammation of gastric mucosa by H. pylori. Host susceptibility may help to predict H. pylori-infected individuals with a higher risk of gastric adenocarcinoma. The aim of this study was to clarify the effect of IL-8 polymorphism on angiogenesis in the process of gastric carcinogenesis in H. pylori-infected Koreans. The IL-8-251A/T polymorphism was genotyped by PCR-RFLP from a total of 395 subjects; 92 normal controls, 87 H. pylori-infected controls, 108 chronic atrophic gastritis and/or intestinal metaplasia and 108 adenocarcinoma. The gastric mucosal concentrations of IL-8, membrane metalloproteinase (MMP)-9, angiopoietin (Ang)-1, and vascular endothelial growth factor (VEGF) were measured by ELISA. MMP-9 concentrations were increased with disease progression. There was significant correlation between MMP-9 and disease progression in AA (r= 0.42, p<0.01) and AT genotype (r= 0.43, p<0.01). Ang-1 concentrations were increased in AA genotype (r= 0.40, p= 0.01). However, there was no significant correlation between VEGF and disease progression in AA genotype. In conclusion, IL-8-251 AA genotype may be associated with angiogenesis in gastric carcinogenesis in H. pylori-infected Koreans. © 2010 Elsevier Ltd.-
dc.languageEnglish-
dc.titleThe interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume51-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage158-
dc.relation.lastpage165-
dc.relation.journaltitleCytokine-
dc.identifier.doi10.1016/j.cyto.2010.05.001-
dc.identifier.wosidWOS:000280027700008-
dc.identifier.scopusid2-s2.0-77954084304-
dc.author.googleSong J.H.-
dc.author.googleKim S.G.-
dc.author.googleJung S.-A.-
dc.author.googleLee M.K.-
dc.author.googleJung H.C.-
dc.author.googleSong I.S.-
dc.contributor.scopusid정성애(7403676915;57360970200)-
dc.date.modifydate20220126130418-
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의과대학 > 의학과 > Journal papers
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