Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경효 | * |
dc.date.accessioned | 2016-08-28T12:08:24Z | - |
dc.date.available | 2016-08-28T12:08:24Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-6682 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220876 | - |
dc.description.abstract | To evaluate the safety and immunogenicity of a new Haemophilus influenzae type b tetanus toxoid conjugate vaccine, LBVH0101 (LG Life Sciences, Ltd.), an open-label, single-arm, phase I study was conducted in twenty healthy adults aged 19 years or older. The subjects were followed for 1 month after administration of a single dose of the vaccine and serum anti-PRP antibody was measured before and 1 month after administration. Among 20 vaccinated subjects, each 10 subjects (50%) reported at least one local and systemic adverse event within 7 days after the vaccination, respectively. Most of the local and systemic adverse events were mild in intensity and resolved within 7 days. There was no death or treatment-related serious adverse event. Geometric mean titers (GMTs) of anti-PRP antibody before and 1 month after the vaccination were 0.71 μg/mL (95% Confidence Interval [CI]: 0.32-1.58,) and 70.26 μg/mL (95% CI: 46.65-105.82), respectively, demonstrating the GMT of anti-PRP antibody at post-vaccination was approximately 98 times higher than that of pre-vaccination. Taken together, LBVH0101 appeared to be safe and well-tolerated and showed good immunogenicity in Korean healthy adults. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands. | * |
dc.language | English | * |
dc.title | An open-label, single-arm, phase i study to evaluate the safety and immunogenicity of LBVH0101, a new Haemophilus influenzae type b tetanus toxoid conjugate vaccine, in healthy adult volunteers | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 919 | * |
dc.relation.lastpage | 924 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-010-0615-5 | * |
dc.identifier.wosid | WOS:000279357300016 | * |
dc.identifier.scopusid | 2-s2.0-77954488926 | * |
dc.author.google | Kim N. | * |
dc.author.google | Choi G. | * |
dc.author.google | Lim C.-Y. | * |
dc.author.google | Lee J.-W. | * |
dc.author.google | Kim K.-H. | * |
dc.author.google | Lee H.J. | * |
dc.contributor.scopusid | 김경효(35448653000) | * |
dc.date.modifydate | 20240301081003 | * |