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dc.contributor.author김대기-
dc.date.accessioned2016-08-28T12:08:24Z-
dc.date.available2016-08-28T12:08:24Z-
dc.date.issued2010-
dc.identifier.issn0960-894X-
dc.identifier.otherOAK-6679-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220873-
dc.description.abstractA series of 2-pyridyl-substituted pyrazoles (16a-d, 17, 18, and 28a-e) and imidazoles (22 and 23) has been synthesized and evaluated for their ALK5 inhibitory activity in cell-based luciferase reporter assays. Among them, 3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazole-1-carbothioamido)benzamide (28c) showed 96% and 93% inhibition at 0.1 μM in luciferase reporter assays using HaCaT cells transiently transfected with p3TP-luc reporter construct and ARE-luc reporter construct, respectively. © 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleSynthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors-
dc.typeArticle-
dc.relation.issue14-
dc.relation.volume20-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage4228-
dc.relation.lastpage4232-
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters-
dc.identifier.doi10.1016/j.bmcl.2010.05.032-
dc.identifier.wosidWOS:000279258800053-
dc.identifier.scopusid2-s2.0-77953873137-
dc.author.googleDewang P.M.-
dc.author.googleKim D.-K.-
dc.contributor.scopusid김대기(35083694200)-
dc.date.modifydate20220303081001-
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약학대학 > 약학과 > Journal papers
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