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dc.contributor.author서은경-
dc.date.accessioned2016-08-28T12:08:20Z-
dc.date.available2016-08-28T12:08:20Z-
dc.date.issued2010-
dc.identifier.issn0006-8993-
dc.identifier.otherOAK-6628-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220834-
dc.description.abstractAlisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma. © 2010 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.titleEffects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes-
dc.typeArticle-
dc.relation.volume1331-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage20-
dc.relation.lastpage27-
dc.relation.journaltitleBrain Research-
dc.identifier.doi10.1016/j.brainres.2010.03.041-
dc.identifier.wosidWOS:000278667100003-
dc.identifier.scopusid2-s2.0-77951298254-
dc.author.googleLee J.-H.-
dc.author.googleLee Y.-J.-
dc.author.googleKang S.-W.-
dc.author.googleKim Y.-
dc.author.googleShin M.-
dc.author.googleHong M.-
dc.author.googleSeo E.-K.-
dc.author.googleKim S.-H.-
dc.author.googleNah S.-Y.-
dc.author.googleBae H.-
dc.contributor.scopusid서은경(7005953758)-
dc.date.modifydate20170601140137-
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약학대학 > 약학과 > Journal papers
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