Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.date.accessioned | 2016-08-28T12:08:20Z | - |
dc.date.available | 2016-08-28T12:08:20Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0006-8993 | * |
dc.identifier.other | OAK-6628 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220834 | - |
dc.description.abstract | Alisol derivatives are unique protostane-type triterpenoid compounds that are isolated from Alismatis rhizoma, which is a well-known traditional medicine in East Asia. In the present study, we investigated the effects of protostane-type triterpenoids (AA, Alisol A; AB, Alisol B; AB-ac, Alisol B 23-acetate; AC-ac, Alisol C 23-aceteate) on 5-HT-induced currents mediated by the human 5-HT3A receptor expressed in Xenopus laevis oocytes. Co-treatment with triterpenoids regulated the 5-HT-induced inward peak current in a concentration-dependent and reversible manner. In addition, regulation of I5-HT by triterpenoids occurred in a non-competitive manner. Taken together, these results indicate that triterpenoids may regulate the 5-HT3A receptors that are expressed in Xenopus oocytes. Furthermore, this regulation of the ligand-gated ion channel activity by triterpenoids may be one of the pharmacological actions of Alismatis rhizoma. © 2010 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.title | Effects of protostane-type triterpenoids on the 5-HT3A receptor-mediated ion current in Xenopus oocytes | * |
dc.type | Article | * |
dc.relation.volume | 1331 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 20 | * |
dc.relation.lastpage | 27 | * |
dc.relation.journaltitle | Brain Research | * |
dc.identifier.doi | 10.1016/j.brainres.2010.03.041 | * |
dc.identifier.wosid | WOS:000278667100003 | * |
dc.identifier.scopusid | 2-s2.0-77951298254 | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Lee Y.-J. | * |
dc.author.google | Kang S.-W. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Shin M. | * |
dc.author.google | Hong M. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Kim S.-H. | * |
dc.author.google | Nah S.-Y. | * |
dc.author.google | Bae H. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.date.modifydate | 20240118144717 | * |