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dc.contributor.author류재상-
dc.date.accessioned2016-08-28T12:08:19Z-
dc.date.available2016-08-28T12:08:19Z-
dc.date.issued2010-
dc.identifier.issn0960-894X-
dc.identifier.otherOAK-6626-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220832-
dc.description.abstractLavendustin-mimetic small molecules modifying the linker -CH 2-NH- with an 1,2,3-triazole ring have been synthesized via a click chemistry. Two pharmacophoric fragments of lavendustin were varied to investigate chemical space and the auxophoric -CH2-NH- was altered to an 1,2,3-triazole for rapid click conjugation. The small molecules were evaluated against HCT116 colon cancer and CCRF-CEM leukemia cell lines. Among 28 analogues, 3-phenylpropyl ester 26b inhibited CCRF-CEM leukemia cell growth with GI50 value of 0.9 μM. © 2010 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleA rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly-
dc.typeArticle-
dc.relation.issue13-
dc.relation.volume20-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage3930-
dc.relation.lastpage3935-
dc.relation.journaltitleBioorganic and Medicinal Chemistry Letters-
dc.identifier.doi10.1016/j.bmcl.2010.05.014-
dc.identifier.wosidWOS:000278644700021-
dc.identifier.scopusid2-s2.0-77954310547-
dc.author.googleYoon J.-
dc.author.googleRyu J.-S.-
dc.contributor.scopusid류재상(36081118200)-
dc.date.modifydate20170601153005-
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약학대학 > 약학과 > Journal papers
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