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dc.contributor.author한운섭*
dc.contributor.author구혜수*
dc.contributor.author성순희*
dc.contributor.author조민선*
dc.contributor.author이정경*
dc.contributor.author김태헌*
dc.contributor.author송동은*
dc.date.accessioned2016-08-28T12:08:18Z-
dc.date.available2016-08-28T12:08:18Z-
dc.date.issued2010*
dc.identifier.issn1738-1843*
dc.identifier.otherOAK-6608*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220817-
dc.description.abstractBackground: Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods: Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+ T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results: The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions: FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV.*
dc.languageKorean*
dc.titleFrequency of intrahepatic FoxP3+ regulatory T cells during the natural course of chronic hepatitis B: An immunohistochemical study using needle-biopsied liver tissue*
dc.typeArticle*
dc.relation.issue2*
dc.relation.volume44*
dc.relation.indexSCOPUS*
dc.relation.startpage132*
dc.relation.lastpage140*
dc.relation.journaltitleKorean Journal of Pathology*
dc.identifier.doi10.4132/KoreanJPathol.2010.44.2.132*
dc.identifier.wosidWOS:000278474400004*
dc.identifier.scopusid2-s2.0-77955066855*
dc.author.googleBae J.Y.*
dc.author.googleKim H.K.*
dc.author.googleKang H.*
dc.author.googleCheong H.R.*
dc.author.googleSong D.E.*
dc.author.googleSung S.H.*
dc.author.googleKoo H.*
dc.author.googleHan W.S.*
dc.author.googleLee J.K.*
dc.author.googleKim T.-H.*
dc.author.googleChung K.W.*
dc.author.googleCho M.-S.*
dc.contributor.scopusid한운섭(7401899962;24172227800)*
dc.contributor.scopusid구혜수(7102121023;57217717081;56612832400)*
dc.contributor.scopusid성순희(7202731948;58455037400)*
dc.contributor.scopusid조민선(13205279200)*
dc.contributor.scopusid이정경(35316081600)*
dc.contributor.scopusid김태헌(57125156300;57219781484)*
dc.contributor.scopusid송동은(8067047700)*
dc.date.modifydate20240123094344*


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