Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한운섭 | * |
dc.contributor.author | 구혜수 | * |
dc.contributor.author | 성순희 | * |
dc.contributor.author | 조민선 | * |
dc.contributor.author | 이정경 | * |
dc.contributor.author | 김태헌 | * |
dc.contributor.author | 송동은 | * |
dc.date.accessioned | 2016-08-28T12:08:18Z | - |
dc.date.available | 2016-08-28T12:08:18Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 1738-1843 | * |
dc.identifier.other | OAK-6608 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220817 | - |
dc.description.abstract | Background: Regulatory T cells (Tregs) may contribute to the immunological hyporesponsiveness against hepatitis B virus (HBV), and this can result in chronic infection. Tregs suppress the T cell responses directed against HBV and they protect hepatocytes by down-regulating the immune responses that cause liver damage, but the role of Tregs has not been well characterized. Methods: Fifty four patients were selected and classified into three groups (12 were in the immune-tolerance phase, 35 were in the immune-clearance phase and 7 were in the asymptomatic virus carrier phase). We examined the frequency of CD3+, CD4+ & CD8+ T cells and forkhead box P3 (FoxP3)+ Tregs in the needle-biopsied liver tissue by performing immunohistochemistry. Results: The FoxP3+ Tregs were mainly located at the portal tracts. In the immune-clearance phase, the frequency of FoxP3+ Tregs was significantly increased compared to that of the immune-tolerance group and the asymptomatic carrier group. Increased FoxP3+ T cells were observed in the patients with a higher histologic inflammatory index. No correlation was observed among the numbers of FoxP3+ Tregs, the serum alanine aminotransferase level, detection of HBeAg and the HBV-DNA viral load. Conclusions: FoxP3+ Tregs may play important roles in suppressing the immune response to HBV and the complete elimination of HBV. | * |
dc.language | Korean | * |
dc.title | Frequency of intrahepatic FoxP3+ regulatory T cells during the natural course of chronic hepatitis B: An immunohistochemical study using needle-biopsied liver tissue | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 44 | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 132 | * |
dc.relation.lastpage | 140 | * |
dc.relation.journaltitle | Korean Journal of Pathology | * |
dc.identifier.doi | 10.4132/KoreanJPathol.2010.44.2.132 | * |
dc.identifier.wosid | WOS:000278474400004 | * |
dc.identifier.scopusid | 2-s2.0-77955066855 | * |
dc.author.google | Bae J.Y. | * |
dc.author.google | Kim H.K. | * |
dc.author.google | Kang H. | * |
dc.author.google | Cheong H.R. | * |
dc.author.google | Song D.E. | * |
dc.author.google | Sung S.H. | * |
dc.author.google | Koo H. | * |
dc.author.google | Han W.S. | * |
dc.author.google | Lee J.K. | * |
dc.author.google | Kim T.-H. | * |
dc.author.google | Chung K.W. | * |
dc.author.google | Cho M.-S. | * |
dc.contributor.scopusid | 한운섭(7401899962;24172227800) | * |
dc.contributor.scopusid | 구혜수(7102121023;57217717081;56612832400) | * |
dc.contributor.scopusid | 성순희(7202731948;58455037400) | * |
dc.contributor.scopusid | 조민선(13205279200) | * |
dc.contributor.scopusid | 이정경(35316081600) | * |
dc.contributor.scopusid | 김태헌(57125156300;57219781484) | * |
dc.contributor.scopusid | 송동은(8067047700) | * |
dc.date.modifydate | 20240123094344 | * |