Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황은숙 | * |
dc.date.accessioned | 2016-08-28T12:08:16Z | - |
dc.date.available | 2016-08-28T12:08:16Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.other | OAK-6590 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220800 | - |
dc.description.abstract | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non- Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properlycited. The third lineage of T helper subsets, Th17, has recently been identified as an IL-17-producing CD4+ Th cell, and its functions and regulatory mechanisms have been extensively characterized in immune responses. Functional studies have provided evidence that Th17 cells are important for the modulation of autoim- mune responses, such as chronic asthma, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. Murine Th17 cell differentiation is enhanced by the coordinated functions of distinct cytokines including TGFβ, IL-6, IL-21, and IL-23, whereas IL-2, IL-4, IFNγ, and IL-27 inhibit its differentiation. In addition, Th17 cells are controlled by several transcription factors such as RORγ t, IRF4, BATF, FoxP3, T-bet, PPARγ, E-FABP, and SOCSs. This review focuses on the functions and regulatory mechanisms of several transcription factors in the control of Th17 cell differentiation. © Yonsei University College of Medicine 2010. | * |
dc.language | English | * |
dc.title | Transcriptional regulation of T helper 17 cell differentiation | * |
dc.type | Review | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 51 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 484 | * |
dc.relation.lastpage | 491 | * |
dc.relation.journaltitle | Yonsei Medical Journal | * |
dc.identifier.doi | 10.3349/ymj.2010.51.4.484 | * |
dc.identifier.wosid | WOS:000278241100002 | * |
dc.identifier.scopusid | 2-s2.0-77956215618 | * |
dc.author.google | Hwang E.S. | * |
dc.contributor.scopusid | 황은숙(8688011100) | * |
dc.date.modifydate | 20240123102458 | * |