Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한기환 | * |
dc.date.accessioned | 2016-08-28T12:08:12Z | - |
dc.date.available | 2016-08-28T12:08:12Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0730-2312 | * |
dc.identifier.other | OAK-6538 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220758 | - |
dc.description.abstract | Although cannabinoids are associated with antineoplastic activity in a number of cancer cell types, the effect in gastric cancer cells has not been clarified. In the present study, we investigated the effects of a cannabinoid agonist on gastric cancer cell proliferation and invasion. The cannabinoid agonist WIN 55,212-2 inhibited the proliferation of human gastric cancer cells in a dose-dependent manner and that this effect was mediated partially by the CB1 receptor. We also found that WIN 55,212-2 induced apoptosis and down-regulation of the phospho-AKT expression in human gastric cancer cells. Furthermore, WIN 55,212-2 treatment inhibited the invasion of gastric cancer cells, and down-regulated the expression of MMP-2 and VEGF-A through the cannabinoid receptors. Our results open the possibilities in using cannabinoids as a new gastric cancer therapy. © 2010 Wiley-Liss, Inc. | * |
dc.language | English | * |
dc.title | Effect of a synthetic cannabinoid agonist on the proliferation and invasion of gastric cancer cells | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 110 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 321 | * |
dc.relation.lastpage | 332 | * |
dc.relation.journaltitle | Journal of Cellular Biochemistry | * |
dc.identifier.doi | 10.1002/jcb.22540 | * |
dc.identifier.wosid | WOS:000277482700007 | * |
dc.identifier.scopusid | 2-s2.0-77952063705 | * |
dc.author.google | Xian X.-S. | * |
dc.author.google | Park H. | * |
dc.author.google | Cho Y.K. | * |
dc.author.google | Lee I.S. | * |
dc.author.google | Kim S.W. | * |
dc.author.google | Choi M.-G. | * |
dc.author.google | Chung I.-S. | * |
dc.author.google | Han K.-H. | * |
dc.author.google | Park J.M. | * |
dc.contributor.scopusid | 한기환(14622504200) | * |
dc.date.modifydate | 20240123095704 | * |