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dc.contributor.author이공주-
dc.contributor.author이수영-
dc.contributor.author강상원-
dc.contributor.author김재상-
dc.contributor.author이두재-
dc.date.accessioned2016-08-28T12:08:58Z-
dc.date.available2016-08-28T12:08:58Z-
dc.date.issued2010-
dc.identifier.issn1932-6203-
dc.identifier.otherOAK-6388-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220631-
dc.description.abstractCytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown. In this study, we demonstrate that the cytosolic Hsp60 promotes the TNF-α-mediated activation of the IKK/NF-kB survival pathway via direct interaction with IKKa/b in the cytoplasm. Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody diminished the IKK/NF-kB activation and the expression of NF-kB target genes, such as Bfl-1/A1 and MnSOD, which thus augmented intracellular ROS production and ASK1-dependent cell death, in response to TNF-α. Conversely, the ectopic expression of cytosol-targeted Hsp60 enhanced IKK/NF-kB activation. Mechanistically, the cytosolic Hsp60 enhanced IKK activation via upregulating the activation-dependent serine phosphorylation in a chaperone-independent manner. Furthermore, transgenic mouse study showed that the cytosolic Hsp60 suppressed hepatic cell death induced by diethylnitrosamine in vivo. The cytosolic Hsp60 is likely to be a regulatory component of IKK complex and it implicates the first mitochondrial factor that regulates cell survival via NF-kB pathway. © 2010 Chun et al.-
dc.languageEnglish-
dc.titleCytosolic Hsp60 Is Involved in the NF-kB-Dependent Survival of Cancer Cells via IKK Regulation-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume5-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitlePLoS ONE-
dc.identifier.doi10.1371/journal.pone.0009422-
dc.identifier.wosidWOS:000275894400003-
dc.identifier.scopusid2-s2.0-79952116841-
dc.author.googleChun J.N.-
dc.author.googleChoi B.-
dc.author.googleLee K.W.-
dc.author.googleLee D.J.-
dc.author.googleKang D.H.-
dc.author.googleLee J.Y.-
dc.author.googleSong I.S.-
dc.author.googleKim H.I.-
dc.author.googleLee S.-H.-
dc.author.googleKim H.S.-
dc.author.googleLee N.K.-
dc.author.googleLee S.Y.-
dc.author.googleLee K.-J.-
dc.author.googleKim J.-
dc.author.googleKang S.W.-
dc.contributor.scopusid이공주(7501497635)-
dc.contributor.scopusid이수영(53980218900;7409697278)-
dc.contributor.scopusid강상원(55731433900)-
dc.contributor.scopusid김재상(8643335800)-
dc.contributor.scopusid이두재(26652094200)-
dc.date.modifydate20210915112011-


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