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dc.contributor.author김대기-
dc.date.accessioned2016-08-28T12:08:58Z-
dc.date.available2016-08-28T12:08:58Z-
dc.date.issued2010-
dc.identifier.issn0033-8419-
dc.identifier.otherOAK-6385-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220629-
dc.description.abstractPurpose: To evaluate the efficacy of an activin receptor-like kinase-5 inhibitor, IN-1233, for the prevention of tissue hyperplasia after bare stent placement in a rat urethral model. Materials and Methods: Procedures were performed in accordance with the National Institutes of Health guidelines for humane handling of animals; approval of the committee of animal research was obtained. In 20 Sprague-Dawley male rats (weight range, 300-350 g), a self-expanding metallic bare stent was inserted in the urethra by using fluoroscopic guidance. One group of 10 rats (group A) was treated with IN-1233, the other group of 10 rats (group B) received no treatment. Retrograde urethrography was performed 4 and 8 weeks after stent placement. All rats were sacri-ficed at 8 weeks for histologic analysis. Results: Stent placement was technically successful in all rats. The average stent diameter was significantly larger in group A compared with group B at follow-up retrograde urethrography performed 4(P =.006) and 8(P < .001) weeks after stent placement. At histologic analysis, the percentage of granulation tissue area(P < .001), thickness of submucosal fibrosis ( P < .001), and number of epithelial layers(P < .001) were significantly decreased in group A compared with group B. Inflammatory cell infiltration(P < .001) was significantly increased in group A compared with group B. Conclusion: IN-1233 is effective for the prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model. © RSNA, 2010.-
dc.languageEnglish-
dc.titleIN-1233, an ALK-5 inhibitor: Prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume255-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage75-
dc.relation.lastpage82-
dc.relation.journaltitleRadiology-
dc.identifier.doi10.1148/radiol.09090670-
dc.identifier.wosidWOS:000275863000011-
dc.identifier.scopusid2-s2.0-77950415363-
dc.author.googleKim J.H.-
dc.author.googleSong H.-Y.-
dc.author.googlePark J.-H.-
dc.author.googleYoon H.-J.-
dc.author.googlePark H.G.-
dc.author.googleKim D.-K.-
dc.contributor.scopusid김대기(35083694200)-
dc.date.modifydate20220303081001-
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약학대학 > 약학과 > Journal papers
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