Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2016-08-28T12:08:58Z | - |
dc.date.available | 2016-08-28T12:08:58Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0033-8419 | * |
dc.identifier.other | OAK-6385 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220629 | - |
dc.description.abstract | Purpose: To evaluate the efficacy of an activin receptor-like kinase-5 inhibitor, IN-1233, for the prevention of tissue hyperplasia after bare stent placement in a rat urethral model. Materials and Methods: Procedures were performed in accordance with the National Institutes of Health guidelines for humane handling of animals; approval of the committee of animal research was obtained. In 20 Sprague-Dawley male rats (weight range, 300-350 g), a self-expanding metallic bare stent was inserted in the urethra by using fluoroscopic guidance. One group of 10 rats (group A) was treated with IN-1233, the other group of 10 rats (group B) received no treatment. Retrograde urethrography was performed 4 and 8 weeks after stent placement. All rats were sacri-ficed at 8 weeks for histologic analysis. Results: Stent placement was technically successful in all rats. The average stent diameter was significantly larger in group A compared with group B at follow-up retrograde urethrography performed 4(P =.006) and 8(P < .001) weeks after stent placement. At histologic analysis, the percentage of granulation tissue area(P < .001), thickness of submucosal fibrosis ( P < .001), and number of epithelial layers(P < .001) were significantly decreased in group A compared with group B. Inflammatory cell infiltration(P < .001) was significantly increased in group A compared with group B. Conclusion: IN-1233 is effective for the prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model. © RSNA, 2010. | * |
dc.language | English | * |
dc.title | IN-1233, an ALK-5 inhibitor: Prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 255 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 75 | * |
dc.relation.lastpage | 82 | * |
dc.relation.journaltitle | Radiology | * |
dc.identifier.doi | 10.1148/radiol.09090670 | * |
dc.identifier.wosid | WOS:000275863000011 | * |
dc.identifier.scopusid | 2-s2.0-77950415363 | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Song H.-Y. | * |
dc.author.google | Park J.-H. | * |
dc.author.google | Yoon H.-J. | * |
dc.author.google | Park H.G. | * |
dc.author.google | Kim D.-K. | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |