DSpace at EWHA: Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity

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DC Field	Value	Language
dc.contributor.author	박혜영	*
dc.contributor.author	김화정	*
dc.date.accessioned	2016-08-28T12:08:57Z	-
dc.date.available	2016-08-28T12:08:57Z	-
dc.date.issued	2010	*
dc.identifier.issn	0968-0896	*
dc.identifier.other	OAK-6366	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220614	-
dc.description.abstract	A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)but-2-enamide showed most favorable bradykinin inhibitory activity and demonstrated analgesic efficacies in the rat models of inflammatory and neuropathic pain. © 2010.	*
dc.language	English	*
dc.title	Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity	*
dc.type	Article	*
dc.relation.issue	6	*
dc.relation.volume	18	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	2327	*
dc.relation.lastpage	2336	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry	*
dc.identifier.doi	10.1016/j.bmc.2010.01.050	*
dc.identifier.wosid	WOS:000275513700029	*
dc.identifier.scopusid	2-s2.0-77649238323	*
dc.author.google	Kam Y.L.	*
dc.author.google	Rhee H.-K.	*
dc.author.google	Kim H.-J.	*
dc.author.google	Back S.K.	*
dc.author.google	Na H.S.	*
dc.author.google	Choo H.-Y.P.	*
dc.contributor.scopusid	박혜영(34972649500;57200273796)	*
dc.contributor.scopusid	김화정(56670336100)	*
dc.date.modifydate	20240118124308	*