NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
자연과학대학
생명과학전공
Journal papers
View : 584 Download: 0
Selenium attenuates Aβ production and Aβ-induced neuronal death
Title
Selenium attenuates Aβ production and Aβ-induced neuronal death
Authors
Gwon A.-R.
;
Park J.-S.
;
Park J.-H.
;
Baik S.-H.
;
Jeong H.-Y.
;
Hyun D.-H.
;
Park K.W.
;
Jo D.-G.
Ewha Authors
현동훈
SCOPUS Author ID
현동훈
Issue Date
2010
Journal Title
Neuroscience Letters
ISSN
0304-3940
Citation
Neuroscience Letters vol. 469, no. 3, pp. 391 - 395
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
The objective of the present study was to examine the role of selenium in the metabolism of Aβ and in Aβ-induced neuronal death. Selenium treatment significantly reduced Aβ40, Aβ42, and sAPPβ production by reducing Aβ producing β-secretase and γ-secretase activities. The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of β-secretase (BACE1) was blocked by selenium. Finally, our data show that selenium protects against HNE and Aβ-mediated toxicity in primary cultured neurons. The present study suggests that selenium may be able to salvage the neuronal degeneration of Alzheimer's disease, thereby limiting β-amyloid production and neuronal death. © 2009 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.neulet.2009.12.035
Appears in Collections:
자연과학대학
>
생명과학전공
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject