Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최병옥 | * |
dc.contributor.author | 조인호 | * |
dc.date.accessioned | 2016-08-28T12:08:47Z | - |
dc.date.available | 2016-08-28T12:08:47Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0969-9961 | * |
dc.identifier.other | OAK-6257 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220518 | - |
dc.description.abstract | Neuromyelitis optica (NMO) is a severe idiopathic inflammatory disease of the central nervous system primarily affecting the optic nerves and spinal cord. In this study, we generated genome-wide SNP data from NMO patients and normal controls (53 cases and 240 controls), and followed up on the association signals with samples from a larger number of inflammatory demyelinating diseases, including NMO (n = 93), multiple sclerosis (MS, n = 71), idiopathic recurrent transverse myelitis (IRTM, n = 57), and normal controls (n = 240). Statistical analyses revealed that a common promoter SNP in CYP7A1 has a protective/gene dose-dependent effect on the risk of NMO (P = 0.0004). A stronger association between the variables and subsequently, a higher protective effect (lower OR) on the risk of NMO were observed among patients carrying the "G/G" genotype of rs3808607 than those with the "T/G" genotype (OR = 0.38/P = 0.01 vs. OR = 0.12/P = 0.0004, respectively). The associations which were only observed in patients with NMO suggest that there are differences in the genetic etiology of the inflammatory demyelinating diseases (NMO, classical MS, and IRTM). © 2009 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Common CYP7A1 promoter polymorphism associated with risk of neuromyelitis optica | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 349 | * |
dc.relation.lastpage | 355 | * |
dc.relation.journaltitle | Neurobiology of Disease | * |
dc.identifier.doi | 10.1016/j.nbd.2009.10.013 | * |
dc.identifier.wosid | WOS:000274224400014 | * |
dc.identifier.scopusid | 2-s2.0-73049089684 | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Park H.-Y. | * |
dc.author.google | Kim E. | * |
dc.author.google | Lee K.-S. | * |
dc.author.google | Kim K.-K. | * |
dc.author.google | Choi B.-O. | * |
dc.author.google | Kim S.M. | * |
dc.author.google | Bae J.S. | * |
dc.author.google | Lee S.O. | * |
dc.author.google | Chun J.Y. | * |
dc.author.google | Park T.J. | * |
dc.author.google | Cheong H.S. | * |
dc.author.google | Jo I. | * |
dc.author.google | Shin H.D. | * |
dc.contributor.scopusid | 최병옥(7402755390) | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.date.modifydate | 20240123112949 | * |