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약학대학
약학과
Journal papers
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Pharmacokinetics of itraconazole in diabetic rats
Title
Pharmacokinetics of itraconazole in diabetic rats
Authors
Lee U.
;
Choi Y.H.
;
Kim S.H.
;
Lee B.K.
Ewha Authors
이병구
SCOPUS Author ID
이병구
Issue Date
2010
Journal Title
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
Citation
Antimicrobial Agents and Chemotherapy vol. 54, no. 2, pp. 931 - 933
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
After intravenous or oral administration of 10 mg/kg itraconazole to rats with streptozotocin-induced diabetes mellitus and to control rats, the total area under the plasma concentration-time curve from time 0 to 24 h (AUC 0-24) for itraconazole and that for its metabolite, 7-hydroxyitraconazole, were similar between the two groups of rats. This may be explained by the comparable hepatic and intestinal intrinsic clearance rates for the disappearance of itraconazole and the formation of 7-hydroxyitraconazole in both groups of rats. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
DOI
10.1128/AAC.01145-09
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