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dc.contributor.author강상원*
dc.date.accessioned2016-08-28T12:08:42Z-
dc.date.available2016-08-28T12:08:42Z-
dc.date.issued2010*
dc.identifier.issn0008-6363*
dc.identifier.otherOAK-6204*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220470-
dc.description.abstractAimsA reduction in the level of thioredoxin 1 (Trx1) has been proposed as a possible mechanism for the tumor-specific growth arrest caused by inhibition of histone deacetylases (HDACs). In this study, we investigated the effect of trichostatin A (TSA), a potent HDAC inhibitor, on the proliferation and migration of vascular smooth muscle cells (VSMCs), and we examined the role of reduced Trx1 levels in this effect.Methods and resultsTSA treatment time-dependently decreased Trx1 expression in rat VSMCs at both the mRNA and protein levels. It also enhanced platelet-derived growth factor (PDGF)-induced proliferation and migration of the VSMCs. By potentiating Akt phosphorylation, the siRNA-induced downregulation of Trx1 also enhanced VSMC proliferation and migration in response to PDGF or serum treatment. Consistent with these results, TSA administration increased neointimal thickening in a murine model of post-angioplastic restenosis.ConclusionThese data demonstrate that TSA enhances vascular proliferative activity by downregulating Trx1, thus activating an Akt-dependent pathway. Our results indicate that, in addition to its apoptotic effects in tumour cells, the downregulation of Trx1 has a proliferative role in primary VSMCs.*
dc.languageEnglish*
dc.titleTrichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1*
dc.typeArticle*
dc.relation.issue1*
dc.relation.volume85*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage241*
dc.relation.lastpage249*
dc.relation.journaltitleCardiovascular Research*
dc.identifier.doi10.1093/cvr/cvp263*
dc.identifier.wosidWOS:000273557200029*
dc.identifier.scopusid2-s2.0-72049083765*
dc.author.googleSong S.*
dc.author.googleKang S.W.*
dc.author.googleChoi C.*
dc.contributor.scopusid강상원(55731433900)*
dc.date.modifydate20240118155300*
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자연과학대학 > 생명과학전공 > Journal papers
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