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dc.contributor.author이원준-
dc.date.accessioned2016-08-28T12:08:40Z-
dc.date.available2016-08-28T12:08:40Z-
dc.date.issued2009-
dc.identifier.issn1016-8478-
dc.identifier.otherOAK-6172-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220443-
dc.description.abstractIn this study, the roles of the p38 MAPK, ERK1/2 and JNK signaling pathway in IGF-I-induced AR induction and activation were examined. C2C12 cells were treated with IGF-I in the absence or presence of various inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), and JNK (SP600125). Inhibition of the MAPK pathway with SB203580, PD98059, or SP600125 significantly decreased IGF-I-induced AR phosphorylation and total AR protein expression. IGF-I-induced nuclear fraction of total AR and phosphorylated AR were significantly inhibited by SB203580, PD98059, or SP600125. Furthermore, IGF-I-induced AR mRNA and skeletal α-actin mRNA were blocked by those inhibitors in dose-dependent manner. Confocal images showed that IGF-I-induced AR nuclear translocation from cytosol was significantly blocked by SB203580, PD98059, or SP600125, suggesting that the MAPK pathway regulates IGF-I-induced AR nuclear localization in skeletal muscle cells. The present results suggest that the MAPK pathways are required for the ligand-independent activation of AR by IGF-I in C2C12 skeletal muscle cells. © 2009 The Korean Society for Molecular and Cellular Biology and Springer Netherlands.-
dc.languageEnglish-
dc.titleLigand-independent activation of the androgen receptor by insulin-like growth factor-i and the role of the MAPK pathway in skeletal muscle cells-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume28-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage589-
dc.relation.lastpage593-
dc.relation.journaltitleMolecules and Cells-
dc.identifier.doi10.1007/s10059-009-0167-z-
dc.identifier.wosidWOS:000273244800012-
dc.identifier.scopusid2-s2.0-76649088649-
dc.author.googleKim H.J.-
dc.author.googleLee W.J.-
dc.contributor.scopusid이원준(55934371200)-
dc.date.modifydate20180524081002-
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신산업융합대학 > 체육과학부 > Journal papers
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