Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이원준 | - |
dc.date.accessioned | 2016-08-28T12:08:40Z | - |
dc.date.available | 2016-08-28T12:08:40Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.other | OAK-6172 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220443 | - |
dc.description.abstract | In this study, the roles of the p38 MAPK, ERK1/2 and JNK signaling pathway in IGF-I-induced AR induction and activation were examined. C2C12 cells were treated with IGF-I in the absence or presence of various inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), and JNK (SP600125). Inhibition of the MAPK pathway with SB203580, PD98059, or SP600125 significantly decreased IGF-I-induced AR phosphorylation and total AR protein expression. IGF-I-induced nuclear fraction of total AR and phosphorylated AR were significantly inhibited by SB203580, PD98059, or SP600125. Furthermore, IGF-I-induced AR mRNA and skeletal α-actin mRNA were blocked by those inhibitors in dose-dependent manner. Confocal images showed that IGF-I-induced AR nuclear translocation from cytosol was significantly blocked by SB203580, PD98059, or SP600125, suggesting that the MAPK pathway regulates IGF-I-induced AR nuclear localization in skeletal muscle cells. The present results suggest that the MAPK pathways are required for the ligand-independent activation of AR by IGF-I in C2C12 skeletal muscle cells. © 2009 The Korean Society for Molecular and Cellular Biology and Springer Netherlands. | - |
dc.language | English | - |
dc.title | Ligand-independent activation of the androgen receptor by insulin-like growth factor-i and the role of the MAPK pathway in skeletal muscle cells | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 28 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 589 | - |
dc.relation.lastpage | 593 | - |
dc.relation.journaltitle | Molecules and Cells | - |
dc.identifier.doi | 10.1007/s10059-009-0167-z | - |
dc.identifier.wosid | WOS:000273244800012 | - |
dc.identifier.scopusid | 2-s2.0-76649088649 | - |
dc.author.google | Kim H.J. | - |
dc.author.google | Lee W.J. | - |
dc.contributor.scopusid | 이원준(55934371200) | - |
dc.date.modifydate | 20211210153240 | - |