Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.date.accessioned | 2016-08-28T12:08:40Z | - |
dc.date.available | 2016-08-28T12:08:40Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0014-5793 | * |
dc.identifier.other | OAK-6167 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220439 | - |
dc.description.abstract | We investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression. © 2009 Federation of European Biochemical Societies. | * |
dc.language | English | * |
dc.title | PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 584 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 173 | * |
dc.relation.lastpage | 180 | * |
dc.relation.journaltitle | FEBS Letters | * |
dc.identifier.doi | 10.1016/j.febslet.2009.11.043 | * |
dc.identifier.wosid | WOS:000273209200030 | * |
dc.identifier.scopusid | 2-s2.0-71549119792 | * |
dc.author.google | Park H. | * |
dc.author.google | No A.L.S.M. | * |
dc.author.google | Lee J.-M. | * |
dc.author.google | Chen L. | * |
dc.author.google | Lee S.Y. | * |
dc.author.google | Lee D.-S. | * |
dc.author.google | Yim M. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.date.modifydate | 20240415140424 | * |