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dc.contributor.author이수영-
dc.date.accessioned2016-08-28T12:08:40Z-
dc.date.available2016-08-28T12:08:40Z-
dc.date.issued2010-
dc.identifier.issn0014-5793-
dc.identifier.otherOAK-6167-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220439-
dc.description.abstractWe investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression. © 2009 Federation of European Biochemical Societies.-
dc.languageEnglish-
dc.titlePDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume584-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage173-
dc.relation.lastpage180-
dc.relation.journaltitleFEBS Letters-
dc.identifier.doi10.1016/j.febslet.2009.11.043-
dc.identifier.wosidWOS:000273209200030-
dc.identifier.scopusid2-s2.0-71549119792-
dc.author.googlePark H.-
dc.author.googleNo A.L.S.M.-
dc.author.googleLee J.-M.-
dc.author.googleChen L.-
dc.author.googleLee S.Y.-
dc.author.googleLee D.-S.-
dc.author.googleYim M.-
dc.contributor.scopusid이수영(7409697278)-
dc.date.modifydate20190901081003-
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자연과학대학 > 생명과학전공 > Journal papers
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