Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2016-08-28T12:08:37Z | - |
dc.date.available | 2016-08-28T12:08:37Z | - |
dc.date.issued | 2010 | * |
dc.identifier.issn | 0968-0896 | * |
dc.identifier.other | OAK-6141 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220415 | - |
dc.description.abstract | Designed and synthesized 60 2-thienyl-4-furyl-6-aryl pyridine derivatives were evaluated for their topoisomerase I and II inhibitory activities at 20 μM and 100 μM and cytotoxicity against several human cancer cell lines. Compounds 8, 9, 11-29 showed significant topoisomerase II inhibitory activity and compounds 10 and 11 showed significant topoisomerase I inhibitory activity. Most of the compounds (7-21) possessing 2-(5-chlorothiophen-2-yl)-4-(furan-3-yl) moiety showed higher or similar cytotoxicity against HCT15 cell line as compared to standards. Most of the selected compounds displayed moderate cytotoxicity against MCF-7, HeLa, DU145, and K562 cell lines. Structure-activity relationship study revealed that 2-(5-chlorothiophen-2-yl)-4-(furan-3-yl) moiety has an important role in displaying biological activities. © 2009 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | 2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 18 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 377 | * |
dc.relation.lastpage | 386 | * |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | * |
dc.identifier.doi | 10.1016/j.bmc.2009.10.049 | * |
dc.identifier.wosid | WOS:000272892100041 | * |
dc.identifier.scopusid | 2-s2.0-72049095310 | * |
dc.author.google | Thapa P. | * |
dc.author.google | Karki R. | * |
dc.author.google | Thapa U. | * |
dc.author.google | Jahng Y. | * |
dc.author.google | Jung M.-J. | * |
dc.author.google | Nam J.M. | * |
dc.author.google | Na Y. | * |
dc.author.google | Kwon Y. | * |
dc.author.google | Lee E.-S. | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |