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dc.contributor.author권영주-
dc.date.accessioned2016-08-28T12:08:37Z-
dc.date.available2016-08-28T12:08:37Z-
dc.date.issued2010-
dc.identifier.issn0968-0896-
dc.identifier.otherOAK-6141-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/220415-
dc.description.abstractDesigned and synthesized 60 2-thienyl-4-furyl-6-aryl pyridine derivatives were evaluated for their topoisomerase I and II inhibitory activities at 20 μM and 100 μM and cytotoxicity against several human cancer cell lines. Compounds 8, 9, 11-29 showed significant topoisomerase II inhibitory activity and compounds 10 and 11 showed significant topoisomerase I inhibitory activity. Most of the compounds (7-21) possessing 2-(5-chlorothiophen-2-yl)-4-(furan-3-yl) moiety showed higher or similar cytotoxicity against HCT15 cell line as compared to standards. Most of the selected compounds displayed moderate cytotoxicity against MCF-7, HeLa, DU145, and K562 cell lines. Structure-activity relationship study revealed that 2-(5-chlorothiophen-2-yl)-4-(furan-3-yl) moiety has an important role in displaying biological activities. © 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.title2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume18-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage377-
dc.relation.lastpage386-
dc.relation.journaltitleBioorganic and Medicinal Chemistry-
dc.identifier.doi10.1016/j.bmc.2009.10.049-
dc.identifier.wosidWOS:000272892100041-
dc.identifier.scopusid2-s2.0-72049095310-
dc.author.googleThapa P.-
dc.author.googleKarki R.-
dc.author.googleThapa U.-
dc.author.googleJahng Y.-
dc.author.googleJung M.-J.-
dc.author.googleNam J.M.-
dc.author.googleNa Y.-
dc.author.googleKwon Y.-
dc.author.googleLee E.-S.-
dc.contributor.scopusid권영주(12446435600;57281846700)-
dc.date.modifydate20220119154509-
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약학대학 > 약학과 > Journal papers
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