Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오억수 | - |
dc.date.accessioned | 2016-08-28T12:08:36Z | - |
dc.date.available | 2016-08-28T12:08:36Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.other | OAK-6123 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220404 | - |
dc.description.abstract | Although elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.language | English | - |
dc.title | Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 51 | - |
dc.relation.volume | 284 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 35692 | - |
dc.relation.lastpage | 35701 | - |
dc.relation.journaltitle | Journal of Biological Chemistry | - |
dc.identifier.doi | 10.1074/jbc.M109.054254 | - |
dc.identifier.wosid | WOS:000272645600047 | - |
dc.identifier.scopusid | 2-s2.0-72149109011 | - |
dc.author.google | Ryu H.-Y. | - |
dc.author.google | Lee J. | - |
dc.author.google | Yang S. | - |
dc.author.google | Park H. | - |
dc.author.google | Choi S. | - |
dc.author.google | Jung K.-C. | - |
dc.author.google | Lee S.-T. | - |
dc.author.google | Seong J.-K. | - |
dc.author.google | Han I.-O. | - |
dc.author.google | Oh E.-S. | - |
dc.contributor.scopusid | 오억수(7101967153) | - |
dc.date.modifydate | 20190901081003 | - |