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Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells
- Syndecan-2 functions as a docking receptor for pro-matrix metalloproteinase-7 in human colon cancer cells
- Ryu H.-Y.; Lee J.; Yang S.; Park H.; Choi S.; Jung K.-C.; Lee S.-T.; Seong J.-K.; Han I.-O.; Oh E.-S.
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- Journal of Biological Chemistry
- Journal of Biological Chemistry vol. 284, no. 51, pp. 35692 - 35701
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- Although elevated syndecan-2 expression is known to be crucial for the tumorigenic activity in colon carcinoma cells, how syndecan-2 regulates colon cancer is unclear. In human colon adenocarcinoma tissue samples, we found that both mRNA and protein expression of syndecan-2 were increased, compared with the neighboring normal epithelium, suggesting that syndecan-2 plays functional roles in human colon cancer cells. Consistent with this notion, syndecan-2-overexpressing HT-29 colon adenocarcinoma cells showed enhanced migration/invasion, anchorage-independent growth, and primary tumor formation in nude mice, paralleling their morphological changes into highly tumorigenic cells. In addition, our experiments revealed that syndecan-2 enhanced both expression and secretion of matrix metalloproteinase-7 (MMP-7), directly interacted with pro-MMP-7, and potentiated the enzymatic activity of pro-MMP-7 by activating its processing into the active MMP-7. Collectively, these data strongly suggest that syndecan-2 functions as a docking receptor for pro-MMP-7 in colon cancer cells. © 2009 by The American Society for Biochemistry and Molecular Biology, Inc.
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