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Mobile phone use and risk of tumors: A meta-analysis

Title
Mobile phone use and risk of tumors: A meta-analysis
Authors
Myung S.-K.Ju W.McDonnell D.D.Lee Y.J.Kazinets G.Cheng C.-T.Moskowitz J.M.
Ewha Authors
주웅
SCOPUS Author ID
주웅scopus
Issue Date
2009
Journal Title
Journal of Clinical Oncology
ISSN
0732-183XJCR Link
Citation
Journal of Clinical Oncology vol. 27, no. 33, pp. 5565 - 5572
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose: Case-control studies have reported inconsistent findings regarding the association between mobile phone use and tumor risk. We investigated these associations using a meta-analysis. Methods: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in August 2008. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Of 465 articles meeting our initial criteria, 23 case-control studies, which involved 37,916 participants (12,344 patient cases and 25,572 controls), were included in the final analyses. Compared with never or rarely having used a mobile phone, the odds ratio for overall use was 0.98 for malignant and benign tumors (95% CI, 0.89 to 1.07) in a random-effects meta-analysis of all 23 studies. However, a significant positive association (harmful effect) was observed in a randomeffects meta-analysis of eight studies using blinding, whereas a significant negative association (protective effect) was observed in a fixed-effects meta-analysis of 15 studies not using blinding. Mobile phone use of 10 years or longer was associated with a risk of tumors in 13 studies reporting this association (odds ratio = 1.18; 95% CI, 1.04 to 1.34). Further, these findings were also observed in the subgroup analyses by methodologic quality of study. Blinding and methodologic quality of study were strongly associated with the research group. Conclusion The current study found that there is possible evidence linking mobile phone use to an increased risk of tumors from a meta-analysis of low-biased case-control studies. Prospective cohort studies providing a higher level of evidence are needed. © 2009 by American Society of Clinical Oncology.
DOI
10.1200/JCO.2008.21.6366
Appears in Collections:
의과대학 > 의학과 > Journal papers
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