Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-08-28T12:08:30Z | - |
dc.date.available | 2016-08-28T12:08:30Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-6035 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/220336 | - |
dc.description.abstract | On the basis of a bioisosteric rationale, 4′-thionucleoside analogues of IB-MECA (N6-(3-Iodo-benzyl)-9-(5′-methylaminocarbonyl-β-d- ribofuranosyl)adenine), which is a potent and selective A3 adenosine receptor (AR) agonist, were synthesized from d-gulonic acid γ-lactone. The 4′-thio analogue (5h) of IB-MECA showed extremely high binding affinity (Ki = 0.25 nM) at the human A3AR and was more potent than IB-MECA (Ki = 1.4 nM). Bulky substituents at the 5′-uronamide position, such as cyclohexyl and 2-methylbenzyl, in this series of 2-H nucleoside derivatives were tolerated in A3AR binding, although small alkyl analogues were more potent. © 2009 Elsevier Ltd. | - |
dc.language | English | - |
dc.title | Design and synthesis of N6-substituted-4′-thioadenosine-5′-uronamides as potent and selective human A3 adenosine receptor agonists | - |
dc.type | Article | - |
dc.relation.issue | 23 | - |
dc.relation.volume | 17 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 8003 | - |
dc.relation.lastpage | 8011 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2009.10.011 | - |
dc.identifier.wosid | WOS:000271521000019 | - |
dc.identifier.scopusid | 2-s2.0-72149103824 | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Chinn M. | - |
dc.author.google | Gao Z.-G. | - |
dc.author.google | Patel A. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Moon H.R. | - |
dc.author.google | Jung Y.H. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |