DSpace at EWHA: Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors

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DC Field	Value	Language
dc.contributor.author	권영주	*
dc.date.accessioned	2016-08-28T12:08:29Z	-
dc.date.available	2016-08-28T12:08:29Z	-
dc.date.issued	2009	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-6024	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/220325	-
dc.description.abstract	A total of seven new oxyranylmethyloxy or thiiranylmethyloxy group substituted 5-azaxanthones and -acridones analogues were synthesized and tested for their biological activities for cancer cell lines and topoisomerases. Among the compounds, compound 5, 3-thiiranylmethyloxy-1-hydroxy-5-azaxanthone, showed effective topoisomerase I inhibitory activity, 50% and 27% inhibition ratio at 100 and 20 μM, respectively. This result is the first finding of the function of 5-azaxanthone compounds for topoisomerase I inhibition and can provide a novel skeleton for the anticancer drug development process. © 2009 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors	*
dc.type	Article	*
dc.relation.issue	23	*
dc.relation.volume	19	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	6766	*
dc.relation.lastpage	6769	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2009.09.091	*
dc.identifier.wosid	WOS:000271430400060	*
dc.identifier.scopusid	2-s2.0-71749084307	*
dc.author.google	Cho H.-J.	*
dc.author.google	Jung M.-J.	*
dc.author.google	Kwon Y.	*
dc.author.google	Na Y.	*
dc.contributor.scopusid	권영주(12446435600)	*
dc.date.modifydate	20240123101932	*